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UnknownA novel gene edited rat model of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).
Not available
S-EPMC12546807 | biostudies-literature
Genomics
Novel Knock in Mutation Rat Model for CARASIL
PRJNA1293465 | ENA
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old Htra1 KO and wild type mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. We isolate...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-02 | PXD022298 | JPOST Repository
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old candesartan-treated and nontreated Htra1 KO mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. Htra1-KO m...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-16 | PXD023477 | JPOST Repository
GenomicsMus musculus
Candesartan prevents the progression of arteriopathy in CARASIL model mice.
PRJDB10757 | ENA
GenomicsMus musculus
Candesartan prevents the progression of arteriopathy in CARASIL model mice.
PRJDB10780 | ENA
ProteomicsProteome analysis of brain microvessels from htra1 KO mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathyis) a small-vessel disease caused by loss of function mutaions of htrA1, which cleaves several extracellular matrix proteins. Here, we isolated microvessels from htra1 KO and wild type control mice to...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-03 | PXD009411 | Pride
Small vessel disease Microvessel Carasil 
UnknownHTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature.
Not available
S-EPMC7351529 | biostudies-literature
TranscriptomicsPorphyromonas gingivalis: Control (Wild-type W83) vs. its htrA mutant
Transcriptional profiling of the wild-type and its htrA mutant. Identification of genes that are affected by the htrA mutation in P. gingivalis Keywords: Genetic modification Two-condition experiment, W83 vs. htrA mutant late-log growth phase. Biological replicates: 4 control, 4 mutant, independentl...
ORGANISM(S): Porphyromonas gingivalis 
2010-05-26 | E-GEOD-10027 | biostudies-arrayexpress
UnknownHTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade.
Not available
S-EPMC6611441 | biostudies-literature
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