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MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
MetabolomicsDietary carbohydrate and protein levels affect the growth performance of juvenile peanut worm (Sipunculus nudus): an LC–MS-based metabolomics study
The peanut worm (Sipunculus nudus) is an economically important fishery resource in China. To determine how dietary carbohydrate and protein levels affects the growth performance of juvenile S. nudus and identify the mechanisms underlying observedpatterns, five isoenergetic and isolipidic diets with...
2021-07-16 | MTBLS2887 | MetaboLights
TranscriptomicsTranscription profiling of brown adipose tissue in a glycerol kinase (Gyk) knockout mouse model to define GyKs role in insulin resistance
Glycerol kinase (GK) is at the interface of fat and carbohydrate metabolism and has been implicated in insulin resistance and type 2 diabetes mellitus (T2DM). To define GK's role in insulin resistance, we examined gene expression in brown adipose tissue in a glycerol kinase (Gyk) knockout (KO) mouse...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4656 | biostudies-arrayexpress
TranscriptomicsA comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver
Effects of soy isoflavones, genistein and daidzein, on the hepatic gene expression profile and indices for lipid metabolism were compared in rats. The GeneChip data was normalized and summarized by using SuperNORM data service (Skylight Biotech Inc.). Significance of expressional change among groups...
ORGANISM(S): Rattus norvegicus 
2012-10-10 | E-GEOD-41420 | biostudies-arrayexpress
MetabolomicsPersistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease

OBJECTIVES: Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism remain largely unknown. Herein, we apply ...

2020-01-22 | MTBLS729 | MetaboLights
MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
TranscriptomicsExpression data from mice on a high fat, high carbohydrate diet treated with exenatide
The present study was constructed to confirm previous findings that mice on a high fat diet (HFD) treated by subcutaneous injection with exenatide (EXE) at 3µg/kg once daily for 6 weeks develop exocrine pancreatic injury (Rouse et al. 2014). The present study included 12 weeks of EXE exposure at mu...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-54774 | biostudies-arrayexpress
TranscriptomicsRegulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins. As adaptors, they lack catalytic activity but contain several protein-protein interaction domains, thus playing a critical role in signal transduc...
ORGANISM(S): Drosophila melanogaster 
2016-03-30 | E-MTAB-4612 | biostudies-arrayexpress
TranscriptomicsConsequences of exchanging carbohydrates for proteins in the cholesterol metabolism of mice fed a high-fat diet
Dietary proteins have profound effects on lipid metabolism but the mechanism remains to be elucidated. In the present study, we examined the temporal impact of dietary proteins in isoenergetic high fat diets on lipid metabolism of C57BL/6J mice. Mice were first fed a low protein (P) to carbohydrate ...
ORGANISM(S): Mus musculus 
2012-12-19 | E-GEOD-20260 | biostudies-arrayexpress
ProteomicsMetformin Impairs Intestinal Fructose Metabolism
Objective: To investigate the effects of metformin on intestinal carbohydrate metabolism in vivo. Method: Male mice preconditioned with a high-fat, high-sucrose diet were treated orally with metformin or a control solution for two weeks. Fructose metabolism, glucose production from fructose, and p...
ORGANISM(S): Mus Musculus (mouse) 
2024-04-27 | PXD041833 | JPOST Repository
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