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TranscriptomicsPhenotype and expression profile of S. erythraea rifampicin-resistant (rif) mutants affected in erythromycin production
In this study we have used the rifampicin selection as a tool to genetically improve the erythromycin producer Saccharopolyspora erythraea. Two rifampicin-resistant (rif) mutants, rif1 and rif6, have been characterized in more detail. With respect to the parental strain NRRL2338, rif1 (harboring the...
ORGANISM(S): Saccharopolyspora erythraea 
2009-04-12 | E-GEOD-12017 | biostudies-arrayexpress
GenomicsChIP-seq for PAX8 and histone modifications in Renal Cell Carcinoma cell lines.
In this experiment we analyzed the genome wide occupancy of PAX8 by ChIP-seq in four Renal Cell Carcinoma cell lines. Additionally we performed ChIP-seq also for histone modifications correlated with transcriptional activity (H3K27ac), enhancers (H3K4me1) and promoters (H3K4me3). Unrelated IgG was u...
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7812 | biostudies-arrayexpress
TranscriptomicsATAC-seq in Renal Cell Carcinoma cell lines
In this experiment we profiled the genome wide chromatin accessibility in 4 Renal Cell Carcinoma cell lines.
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7844 | biostudies-arrayexpress
TranscriptomicsRNA-seq upon PAX8 knockdown in Renal Cell Carcinoma cell lines
In this experiment we examined the genes regulated by PAX8 knockdown in four renal cell carcinoma models. Four different cell lines bearing a validated doxycycline (DOX) inducible shRNA against PAX8 were treated with DOX for 96 hours and their gene expression profile analyzed by RNA-seq.
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7808 | biostudies-arrayexpress
TranscriptomicsComparative genomics reveals new molecular targets for accelerated strain improvement of rifamycin B-producing strains
In the present study, we have used a genomic approach to understand how the classical mutate-and-screen method actually generated an improved rifamycin B producer. Compared with the reference strains Amycolatopsis mediterranei S699 (rifamycin B producer) and U32 (rifamycin SV producer), a total of 2...
ORGANISM(S): Amycolatopsis mediterranei S699 
2014-08-26 | E-GEOD-51015 | biostudies-arrayexpress
TranscriptomicsComparative Genomics Reveals New Molecular targets for Accelerated Improvement of Erythromycin-producing Strains
Information about molecular mechanisms underlying improvement of antibiotic-producing microorganisms with traditional mutation and screening approach is largely missing. This information is essential to develop rational approaches to strain improvement. In this study by using comparative genomic ana...
ORGANISM(S): Saccharopolyspora erythraea 
2012-05-23 | E-GEOD-30600 | biostudies-arrayexpress
GenomicsSalt priming A. thaliana ChIP-Seq
A role of chromatin in plant memory of environmental stress has been proposed. In this study ChIP-Seq was employed to investigate whether a transient mild salt treatment of Arabidopsis thaliana plant at seedling stage (M-^Qpriming treatmentM-^R: 50 mM NaCl for 24 hours) altered genome-wide profiles ...
ORGANISM(S): Arabidopsis thaliana 
2013-06-01 | E-MTAB-1663 | biostudies-arrayexpress
UnknownEuropean Guideline on Chronic Nausea and Vomiting-A UEG and ESNM Consensus for Clinical Management.
Not available
S-EPMC11999049 | biostudies-literature
UnknownPattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry.
Not available
S-EPMC7384278 | biostudies-literature
UnknownPrevalence and mortality associated with multidrug-resistant infections in adult intensive care units in Argentina (PREV-AR).
Not available
S-EPMC11881575 | biostudies-literature
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