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TranscriptomicsModulation of gene expression by complement protein C1q in amyloid-beta injured neurons
Complement protein C1q is induced after injury in the brain and during Alzheimer's disease and has been shown to protect against amyloid-beta induced neuronal death. In this study, we used microarray approach to identify the pathways modulated by C1q that are associated with neuroprotection. Immatur...
ORGANISM(S): Rattus norvegicus 
2012-12-21 | E-GEOD-28886 | biostudies-arrayexpress
ProteomicsCardiac Amyloid Tissue Proteome
Cardiac AL and ATTR are potentially fatal cardiomyopathies. Current therapies do not address mechanisms of tissue dysfunction, mostly because these remain unknown. Our prior work has focused on the amyloid plaque proteome, which may not capture tissue-wide proteomic alterations. In this study, we us...
ORGANISM(S): Homo sapiens (Human) 
2025-01-15 | PXD058715 | Pride
Attr Cardiac amyloid Al 
GenomicsAmyloid beta 42 alters cardiac metabolism and impairs cardiac function in obesity
Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in obesity
PRJNA882101 | ENA
TranscriptomicsTranscription profiling of mouse vehicle and sAPPalpha-treated hippocampal slice cultures
Gene expression changes induced by alpha-secretase cleaved amyloid precursor protein (sAPPalpha) in organotypic hippocampal slice cultures of male, postnatal day 15 mice (C57B6/SJL). Hippocampal slice cultures were treated with phosphate buffered saline (GSM26700, GSM26701, GSM26702) or 1 nM sAPPal...
ORGANISM(S): Mus musculus 
2007-10-10 | E-GEOD-1555 | biostudies-arrayexpress
GenomicsThe role of cardiac fibrosis and fibroblast activation in amyloid light chain (AL) amyloidosis
The role of cardiac fibrosis and fibroblast activation in amyloid light chain (AL) amyloidosis
PRJNA1416282 | ENA
ProteomicsMass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis
Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins. In vivo, proteolysis may modulate amyloidogenesis and fibril stability. In light chain (AL) amyloidosis, fragmented light chains (LCs) are abundant components of amyloid deposits; however, site and timing of...
ORGANISM(S): Homo sapiens (Human) 
2020-10-15 | PXD020858 | Pride
Proteolysis Mass spectrometry Amyloid fibrils Proteomics Cardiomyopathy 
ProteomicsSubtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies
Cardiac amyloidosis is a severe clinical condition leading to restrictive cardiomyopathy and heart failure. With increasing options for specific treatment of different cardiac amyloid diseases, correct amyloid subtyping is essential for clinical outcome. Mass spectrometry-based methods for cardiac a...
ORGANISM(S): Homo sapiens (Human) 
2022-10-27 | PXD033168 | Pride
Subtyping Proteomics Endomyocardial biopsies Mass spectrometry Cardiac amyloidosis 
ProteomicsSubtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies
Additional data to PXD033168 Cardiac amyloidosis is a severe clinical condition leading to restrictive cardiomyopathy and heart failure. With increasing options for specific treatment of different cardiac amyloid diseases, correct amyloid subtyping is essential for clinical outcome.
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD047125 | Pride
Proteomics Endomyocardial biopsies Mass spectrometry Cardiac amyloidosis Subtyping 
ProteomicsCryo-EM of cardiac AL-224L amyloid reveals shared features in l6 light chain fibril folds
Structural characterization of an amyloid fibril from a patient afected by cardiac light chain amyloidosis.
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD064296 | Pride
TranscriptomicsTranscription profiling of human SHEP-SF cells expressing AICD and Fe65
The amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimerâ??s disease (AD). Processing of APP by β- and γ-secretase activities results in the production of Ã?-amyloid (AÃ?), the main constituent of Alzheimer plaques, but also in the generation of the APP intracellul...
ORGANISM(S): Homo sapiens 
2007-06-22 | E-GEOD-4097 | biostudies-arrayexpress
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