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ProteomicsCardiac Amyloid Tissue Proteome
Cardiac AL and ATTR are potentially fatal cardiomyopathies. Current therapies do not address mechanisms of tissue dysfunction, mostly because these remain unknown. Our prior work has focused on the amyloid plaque proteome, which may not capture tissue-wide proteomic alterations. In this study, we us...
ORGANISM(S): Homo sapiens (Human) 
2025-01-15 | PXD058715 | Pride
Attr Cardiac amyloid Al 
ProteomicsStructural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy
Identification of ATTR C-terminal fragment by LC/MS QTOF in ATTRv-I84S samples (Supplementary Fig.3 and supplementary table 1) 1126546: Patient 2 1126547: Patient 3 1126548 :Patient 1
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-06 | MSV000093061 | MassIVE
UnknownQuality of life assessment in amyloid transthyretin (ATTR) amyloidosis.
Not available
S-EPMC8596396 | biostudies-literature
ProteomicsRac1 inhibition prevents cytoskeleton dysfunction and axonal degeneration in Transthyretin Amyloid Polyneuropathy
Transthyretin Amyloid Polyneuropathy (ATTR-PN) is characterized by the deposition of amyloidogenic TTR particularly in dorsal root ganglia (DRG) and peripheral nerve axons leading to a sensory axonopathy. Here, we investigated the role of cytoskeleton alterations in peripheral axons from an ATTR-PN ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-10 | PXD054291 | Pride
Transthyretin  axonopathy  transthyretin amyloid polyneuropathy  cytoskeleton  microtubule dynamics  actin  axonal transport  peripheral nervous system  rac1 
UnknownMusculoskeletal manifestations associated with transthyretin-mediated (ATTR) amyloidosis: a systematic review.
Not available
S-EPMC10517539 | biostudies-literature
UnknownCharacterization of heterozygous ATTR Tyr114Cys amyloidosis-specific induced pluripotent stem cells.
Not available
S-EPMC10835262 | biostudies-literature
UnknownNatural history and progression of transthyretin amyloid cardiomyopathy: insights from ATTR-ACT.
Not available
S-EPMC8497209 | biostudies-literature
UnknownConventional heart failure therapy in cardiac ATTR amyloidosis.
Not available
S-EPMC10424879 | biostudies-literature
UnknownWhole tissue proteomic analyses of cardiac ATTR and AL unveil mechanisms of tissue damage.
Not available
S-EPMC11825277 | biostudies-literature
UnknownPrevalence of anxiety and depression symptoms in a sample of outpatients with ATTR cardiac amyloidosis.
Not available
S-EPMC9889831 | biostudies-literature
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