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MetabolomicsCardiac untargeted lipidomics in cardiomyocyte-specific Srebp1a-Tg mice

Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider...

2026-02-20 | MTBLS13690 | MetaboLights
MetabolomicsCardiac untargeted lipidomics in cardiomyocyte-specific SREBP1 knockdown mice

Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider...

2026-02-20 | MTBLS13696 | MetaboLights
TranscriptomicsReversible and irreversible differentiation of cardiac fibroblasts
Aim: Differentiation of cardiac fibroblasts (Fb) into myofibroblasts (MyoFb) is responsible for connective tissue buildup in myocardial remodeling. We examined reversibility of MyoFb differentiation. Methods and Results: Adult rat cardiac Fb were cultured on a plastic substratum providing mechanical...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-51824 | biostudies-arrayexpress
MetabolomicsZEB1 Maintains Energy Metabolism to Sustain Cardiac Function Through Synergistic Regulation with TEAD1
Metabolic reprogramming plays a critical role in heart failure (HF), but its regulatory mechanisms remain incompletely understood. Zinc finger E-box binding homeobox 1 (ZEB1), a transcription factor initially identified as a regulator of epithelial-mesenchymal transition, has recently been implicate...
2026-09-28 | MTBLS15833 | MetaboLights
TranscriptomicsTMEM88 knockdown during human embryonic stem cell cardiac differentiation
TMEM88 is indispensable for heart development and acts in the pre-cardiac mesoderm to specify lineage commitment of the cardiovascular progenitor cell through inhibition of Wnt signaling. 2 different lentiviruses expression shRNA targeting different domains of the TMEM88 locus were transduced into u...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-43805 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of mouse ESC cardiomyocyte-specific differentiation
The differentiation to cardiomyocytes is a prerequisite and an important part of heart development. A good understanding of the complicated cardiomyocyte differentiation process benefits cardiogenesis study. Embryonic stem cells (ESCs), cell lines with infinite ability to proliferate and to be diffe...
ORGANISM(S): Mus musculus 
2014-09-25 | E-GEOD-58300 | biostudies-arrayexpress
Transcriptomics3'SRP data of cardiac differentiation of human induced pluripotent stem cell control lines
Human heart development is governed by transcription factor (TF) networks controlling dynamic and temporal gene expression alterations. Therefore, to comprehensively characterize these transcriptional regulations, day-to-day transcriptomic profiles were generated throughout the directed cardiac diff...
ORGANISM(S): Homo sapiens 
2022-12-06 | E-MTAB-11822 | biostudies-arrayexpress
ProteomicsProteomics identification of regulated proteins during cardyomyocyte differentiation
The rat cardio-myoblast cell line H9C2 has emerged as an important tool for studying cardiac development and toxicology. We present here a rigorous proteomic analysis that for the first time studied changes of proteins during H9C2 differentiation into cardiomyocyte-like cells over time. Quantitative...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-11-07 | PXD006115 | Pride
Rattus norvegicus Labelfree shotgun proteomics Cardiac development H9c2 cells 
TranscriptomicsTranscriptional Reversion of Cardiac Myocyte Fate During Mammalian Cardiac Regeneration.
Rationale: Neonatal mice have the capacity to regenerate their hearts in response to injury, but this potential is lost after the first week of life. The transcriptional changes that underpin mammalian cardiac regeneration have not been fully characterized at the molecular level. Objective: The obje...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-64403 | biostudies-arrayexpress
TranscriptomicsExpression data from human iPS cells treated by a small molecule KY02111
Human pluripotent stem cells (hPSCs) such as embryonic stem cells and induced pluripotent stem cells are promising materials for cell-based regenerative therapies to heart diseases. However, until realization there are many hurdles such as high efficiency of cardiac differentiation of hPSCs and prod...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-33622 | biostudies-arrayexpress
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