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ProteomicsMBD2 modulates heterochromatin architecture and composition
Heterochromatin (HC) is essential for nuclear integrity, genome stability, and gene regulation with pericentric heterochromatin (PCH) playing a key role. However, the mechanisms governing PCH compartmentalization remain poorly understood. Recent studies suggest that phase separation (PS) underlies t...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD055626 | Pride
Mice brain Dia-ms Mbd2 Pericentric heterochromatin Alphafold server Nuclear fractionation Ps prediction tools Phase separation 
ProteomicsThe proteomic composition of constitutive heterochromatin in mouse tissues
Pericentric heterochromatin (PCH) forms spatially and temporarily distinct compartments from other nuclear fractions and plays an important role in nuclei organization and genome stability. This highlights the necessity of elucidating the protein compositions of PCH. We find that the PCH compartment...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD045223 | Pride
Mouse Brain Liver Hplc-ms/ms 
ProteomicsMeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
Rett syndrome is a human intellectual disability disorder that is associated with mutations in the X-linked MECP2 gene. Theepigenetic reader MeCP2 binds to methylated cytosines on the DNA and regulates chromatin organization. We have shownpreviously that MECP2 Rett syndrome missense mutations are im...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD033696 | Pride
Lc-ms/ms Brain Mouse 
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
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S-EPMC7272903 | biostudies-literature
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