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TranscriptomicsTranscription profiling of pooled human CD3+ cells in duplicate from healthy controls vs. patients with active chronic idiopathic thrombocytopenic purpura (ITP) and ITP in remission.
CD3+ cells were studied in duplicate from healthy controls, patients with active ITP and ITP in remission.
ORGANISM(S): Homo sapiens 
2007-09-28 | E-GEOD-574 | biostudies-arrayexpress
ProteomicsMass-spectrometry analysis of brain endothelial cells (BECs) from Foxf2iECKO and Ctrl mice
To identify the molecular and cellular pathways mediating the effects of Foxf2 in brain endothelial cells (BECs), we performed proteomic analysis of mouse BECs. For this, we applied our previously published BEC enrichment protocol using magnetic-activated cell sorting (MACS) combined with liquid chr...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-02 | PXD051838 | Pride
Barin endothelial cells Foxf2 Tie2 Mouse 
ProteomicsMass-spectrometry analysis of vehicle or AKB-9778 treated FOXF2KO and WT human endothelial cells
To validate our results on Foxf2 related Tie2 signaling and explore their transferability to human cells, we studied human iPSC-derived endothelial cells (iECs). FOXF2KO and WT iECs (González-Gallego et al., in preparation) were treated with AKB-9778 or vehicle and assessed by proteomics. Similar to...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD051855 | Pride
Small vessel disease Foxf2 Akb-9778 Tie2 Endothelial cell 
ProteomicsMass-spectrometry analysis of isolated brain vessels from vehicle treated Foxf2iECKO, vehicle-treated Ctrl, and AKB-9778 treated Foxf2iECKO mice
To further characterize the role of endothelial Foxf2 in the maintenance of vascular function and examine a possible mediating effect of Tie2 signaling, we pharmacologically modulated Tie2 activity in mice and performed subsequent in vivo analyses together with studies on isolated brain vessels. Spe...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-02 | PXD051839 | Pride
Small vessel disease Foxf2 Tie2 Microvessel 
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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