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ProteomicsShulin packages axonemal outer dynein arms for ciliary targeting
The main force generators in eukaryotic cilia and flagella are axonemal outer dynein arms (ODAs). During cilio-genesis, these ∼1.8 MDa complexes are assembled in the cytoplasm and targeted to cilia via an unknown mechanism. Here we use the ciliate Tetrahymena to identify two novel factors (Q22YU3 an...
ORGANISM(S): Tetrahymena thermophila CU428 
2021-09-09 | PXD022396 | Pride
Cilia Tetrahymena thermophila Dynein Cryo-em Lc-ms/ms Flagella 
ProteomicsThe intracellular bacterium Orientia tsutsugamushi uses the autotransporter ScaC to activate BICD adaptors for dynein-based motility.
The intracellular bacterium Orientia tsutsugamushi relies on the microtubule cytoskeleton and the motor protein dynein to traffic to the perinuclear region within infected cells. However, it remains unclear how the bacterium is coupled to the dynein machinery and how transport is regulated. Here, we...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD064516 | Pride
Bicd2 
UnknownPurified Photoreceptor Cell Rootlet Tomograms
Not available
EMPIAR-11828 | biostudies-other
TranscriptomicsComparative genomic hybridization of 61 strains of proteolytic Clostridium botulinum or Clostridium sporogenes
Genomic DNA of 61 strains of proteolytic Clostridium botulinum or Clostridium sporogenes was subjected to analysis by DNA microarray.
ORGANISM(S): Clostridium botulinum 
2008-12-31 | E-MEXP-1637 | biostudies-arrayexpress
ProteomicsCrosslinking/mass spectrometry (CLMS) analysis of Tetrahymena ODA-Q22MS1 complex
The outer dynein arms (ODAs) are the main force generators in cilia. Crosslinking/mass spectrometry (CLMS) was applied to investigate the interaction between ODA and its binding factor Q22MS1.
ORGANISM(S): Tetrahymena 
2021-12-07 | PXD022936 | JPOST Repository
GenomicsMassive genomic rearrangement acquired in a single catastrophic event during cancer development - samples
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
EGAD00001000002 | EGA
GenomicsMassive Genomic Rearrangment Acquired in a Single Catastrophic Event During Cancer Development
Cancer is driven by mutation. Using Agilent exome hybridisation capture and Illumina GA massively parallel sequencing technology, we aim to sequence ~1600 microRNAs plus the protein coding genome of 25 matched human renal cancer samples. Bespoke algorithms are being developed to identify the somatic...
EGAS00000000029 | EGA
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownChallenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives.
Not available
S-EPMC6909648 | biostudies-literature
UnknownCommon genetic variants influence human subcortical brain structures.
Not available
S-EPMC4393366 | biostudies-literature
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