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The main force generators in eukaryotic cilia and flagella are axonemal outer dynein arms (ODAs). During cilio-genesis, these ∼1.8 MDa complexes are assembled in the cytoplasm and targeted to cilia via an unknown mechanism. Here we use the ciliate Tetrahymena to identify two novel factors (Q22YU3 an...
ORGANISM(S): Tetrahymena thermophila CU428 
2021-09-09 | PXD022396 | Pride
Genomic DNA of 61 strains of proteolytic Clostridium botulinum or Clostridium sporogenes was subjected to analysis by DNA microarray.
ORGANISM(S): Clostridium botulinum 
The outer dynein arms (ODAs) are the main force generators in cilia. Crosslinking/mass spectrometry (CLMS) was applied to investigate the interaction between ODA and its binding factor Q22MS1.
ORGANISM(S): Tetrahymena 
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
Cancer is driven by mutation. Using Agilent exome hybridisation capture and Illumina GA massively parallel sequencing technology, we aim to sequence ~1600 microRNAs plus the protein coding genome of 25 matched human renal cancer samples. Bespoke algorithms are being developed to identify the somatic...
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