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TranscriptomicsNormal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression
Activation of inflammatory pathways is one plausible mechanism underlying the association between obesity and increased breast cancer risk. However, macrophage infiltration and local biomarkers of inflammation in breast adipose tissue have seldom been studied in association with obesity. Gene expres...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-33526 | biostudies-arrayexpress
TranscriptomicsRole of HGF in epithelial-stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ
ABSTRACT: Introduction: Basal-like and luminal breast cancers have distinct stromal-epithelial interactions, which likely play a role in progression to invasive cancer. However, little is known about how stromal-epithelial interactions evolve in benign and pre-invasive lesions.Methods: To study epit...
ORGANISM(S): Homo sapiens 
2013-07-12 | E-GEOD-43467 | biostudies-arrayexpress
TranscriptomicsTumor Intrinsic Subtype is Reflected in Cancer-Adjacent Benign Tissue
Introduction: Overall survival of early-stage breast cancer (BC) patients is similar for those who undergo breast conserving therapy (BCT) and mastectomy, however, 10-15% of women undergoing BCT suffer ipsilateral breast tumor recurrence. The risk of recurrence may vary with age or breast cancer sub...
ORGANISM(S): Homo sapiens 
2014-04-30 | E-GEOD-50939 | biostudies-arrayexpress
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