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UnknownDetermination of local chromatin composition by CasID.
Not available
S-EPMC5120596 | biostudies-literature
ProteomicsCasID on RRM2 promoter region in neuroblastoma
dCas9-guided recruitment of the proximity ligation enzyme BirA* to the promoter region of RRM2 in SKNBE2c neuroblastoma cells.
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD029630 | Pride
Neuroblastoma Rrm2 Casid Bioid 
UnknownInvestigating Multi-Target Antiviral Compounds by Screening of Phytochemicals From Neem (Azadirachta indica) Against PRRSV: A Vetinformatics Approach.
Not available
S-EPMC9244183 | biostudies-literature
TranscriptomicsThe dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma [3AP or the combination 3AP-prexasertib]
Neuroblastoma is a pediatric tumor originating from the sympathetic nervous system responsible for 10-15% of all childhood cancer deaths. Half of all neuroblastoma patients present with high-risk disease at diagnosis despite intensive multi-modal therapies of which nearly 50% relapse and die of thei...
ORGANISM(S): Homo sapiens 
2022-08-03 | GSE162202 | GEO
TranscriptomicsThe dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma [compound_3AP]
Neuroblastoma is a pediatric tumor originating from the sympathetic nervous system responsible for 10-15% of all childhood cancer deaths. Half of all neuroblastoma patients present with high-risk disease at diagnosis despite intensive multi-modal therapies of which nearly 50% relapse and die of thei...
ORGANISM(S): Homo sapiens 
2022-08-03 | GSE161900 | GEO
TranscriptomicsThe dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma [siRNA_RRM2]
Neuroblastoma is a pediatric tumor originating from the sympathetic nervous system responsible for 10-15% of all childhood cancer deaths. Half of all neuroblastoma patients present with high-risk disease at diagnosis despite intensive multi-modal therapies of which nearly 50% relapse and die of thei...
ORGANISM(S): Homo sapiens 
2022-08-03 | GSE161899 | GEO
Proteomicshuman adenovirus-host protein interactions
As intracellular parasites, viruses exploit cellular proteins at every stage of infection. Adenovirus related outbreaks cause severe acute respiratory illnesses and conjunctivitis, with no specific antiviral therapy yet available. Herein, we investigate human adenovirus (HAdV-D37) pIIIa-host protein...
ORGANISM(S): Homo sapiens (Human) 
2022-05-30 | PXD023642 | Pride
Affinity purification Casid protein Adenovirus Lc-ms/ms Piiia 
ProteomicsqChIP-MS reveals the local chromatin composition by label-free quantitative proteomics
Chromatin immunoprecipitation (ChIP) has been a cornerstone for epigenetic analyses over the last decades, but even coupled to sequencing approaches (ChIP-seq), it is ultimately limited to one protein at a time. In a complementary effort, we here combine ChIP with label-free quantitative mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-03 | PXD076520 | Pride
GenomicsThe dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma [siRNA_RRM2]
The dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma [siRNA_RRM2]
PRJNA679807 | ENA
GenomicsThe dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma [compound_3AP]
The dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma [compound_3AP]
PRJNA679808 | ENA
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