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ProteomicsLocking CBL in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukaemia (part2)
Casitas B-lineage lymphoma (CBL) is critical to the negative regulation of receptor protein tyrosine kinases (RTKs). Mutant CBL can act as an adaptor and gain function to cause myeloproliferative diseases. Currently, there is no beneficial treatment available for leukaemia patients with CBL mutation...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051179 | Pride
Peptide inhibitor cblock Leukaemia Cbl tyrosine kinase binding domain Casitas b-lineage lymphoma (cbl) 
ProteomicsComparative analysis of WT CBL and CBL 70Z interactomes.
Cbl (Casitas B-lineage lymphoma) is a prominent post-translational regulator of protein tyrosine kinases (PTKs) that targets activated receptors for ubiquitination-mediated degradation. However, mutations within its E3 ubiquitin ligase activity rendering RING domain are often not sufficient to induc...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD011369 | Pride
On-beads digestion. Rtks Ubiquitination Cbl Label-free quantitation Endosomal trafficking 
ProteomicsLocking CBL in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukaemia (part 1)
Casitas B-lineage lymphoma (CBL) is critical to the negative regulation of receptor protein tyrosine kinases (RTKs). Mutant CBL can act as an adaptor and gain function to cause myeloproliferative diseases. Currently, there is no beneficial treatment available for leukaemia patients with CBL mutation...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051178 | Pride
Peptide inhibitor cblock Cbl’s tyrosine kinase binding domain Leukaemia Casitas b-lineage lymphoma (cbl) 
UnknownSinularamides A-G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (Cbl-b) Inhibitory Activities from a Sinularia sp. Soft Coral.
Not available
S-EPMC9341130 | biostudies-literature
UnknownThe Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination.
Not available
S-EPMC3129223 | biostudies-literature
UnknownDevelopment of a fluorescence polarization based high-throughput assay to identify Casitas B-lineage lymphoma RING domain regulators.
Not available
S-EPMC3814989 | biostudies-literature
UnknownHaploinsufficiency of Casitas B-Lineage Lymphoma Augments the Progression of Colon Cancer in the Background of Adenomatous Polyposis Coli Inactivation.
Not available
S-EPMC7074366 | biostudies-literature
UnknownEimeria acervulina Microneme Protein 3 Inhibits Apoptosis of the Chicken Duodenal Epithelial Cell by Targeting the Casitas B-Lineage Lymphoma Protein.
Not available
S-EPMC8204691 | biostudies-literature
UnknownCasitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
Not available
S-EPMC5015263 | biostudies-literature
TranscriptomicsQuantitative Analysis of Wild Type CBL, CBL 70Z and Y371S 3T3 Stable Cell Transcriptomes
Cbl (Casitas B-lineage lymphoma) is a prominent post-translational regulator of protein tyrosine kinases (PTKs) that targets activated receptors for ubiquitination-mediated degradation. However, mutations within its E3 ubiquitin ligase activity rendering RING domain are often not sufficient to induc...
ORGANISM(S): Mus musculus 
2019-10-20 | GSE121176 | GEO
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