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ProteomicsDeciphering and predicting CD4+ T cell immunodominance of Influenza virus hemagglutinin
The importance of CD4+ T helper (Th) cells is well appreciated in view of their essential role in the elicitation of antibody and cytotoxic T cell responses. However, the mechanisms that determine the selection of immunodominant epitopes within complex protein antigens remain elusive. Here, we used ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Influenza A virus (A/California/07-00002/2009(H1N1)) 
2020-06-29 | PXD018151 | Pride
Peptidomics Influenza Mhc-ii Modc Ebv-b Antigen presentation Human Hemagglutinin 
ProteomicsA single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS), but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation. To understand the basi...
ORGANISM(S): Homo sapiens (Human) 
2019-10-10 | PXD013599 | Pride
Antibody therapy Mhc-ii peptidomics Multiple sclerosis Human 
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