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TranscriptomicsTranscription profiling of mouse RAG1 knockout CD4+ T cells to investigate the effect of absence of interaction with MHC class II on memory CD4 T cells
Effect of absence of interaction with MHC class II on memory CD4 T cells
ORGANISM(S): Mus musculus 
2007-03-01 | E-MEXP-890 | biostudies-arrayexpress
ProteomicsHLA-DO Modulates the Diversity of the MHC-II Self-peptidome
HLA-DR1 bound peptides of five biological replicates of LG2-WT(012916_WT1,022216_WT1, 02080316MHCIIWT1, 080316MHCIIWT2, 080316MHCIIWT3) and DO-KO Clone 1 LG-2 cells (012916_KO1, 022216_DO1, 081216MHCIIKO1, 080416MHCIIKO2, 080416MHCIIKO3) were processed in parallel. Each biological replicate has 3 te...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-03 | MSV000082570 | MassIVE
TranscriptomicsEffect of MHC II expression in pro-B cells: Pre-B cells and follicular B cells from wild-type and MHC II conditional mice
Hardy’s Fraction D bone marrow pre-B cells and splenic follicular B cells were purified by flow cytometry according to MHC II expression from wild-type and ItgaxcreH2-Ab1c MHC II conditional mice and transcriptionally profiled by RNA-seq. Duplicate or triplicate samples for each genotype and level o...
ORGANISM(S): Mus musculus 
2018-08-07 | E-MTAB-6765 | biostudies-arrayexpress
TranscriptomicsEffect of MHC II expression in pro-B cells: F6 leukaemic cell line
F6 murine leukaemic cells were transfected either with MHC II or with GFP and transcriptionally profiled by RNA-seq. Triplicate samples for each genotype were sequenced. This is part of ongoing investigation of a possible cell-intrinsic role of MHC II B cells.
ORGANISM(S): Mus musculus 
2018-08-07 | E-MTAB-6763 | biostudies-arrayexpress
ProteomicsImmunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design
No currently licensed vaccine reliably prevents pulmonary tuberculosis, a leading cause of infectious disease mortality with a growing rate of extensive drug resistance. Developing effective new vaccines will likely require identifying Mycobacterium tuberculosis (Mtb)-derived antigens presented on M...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD055952 | Pride
Dendritic cells Tuberculosis Mhc class ii Human Immunopeptidomics 
ProteomicsMHC II immunopeptidome during Plasmodium berghei blood stage infection
In malaria, T cells play a dual role by both restricting parasite growth and mediating immunopathology such as the deadly neuroinflammation called cerebral malaria. During experimental cerebral malaria (ECM), IFN produced by CD4 T cells promotes CD8 T cell sequestration in brain capillaries, result...
ORGANISM(S): Mus musculus (Mouse) Plasmodium berghei ANKA 
2017-09-20 | PXD007628 | Pride
Lc-msms Malaria Mouse Mhc ii Plasmodium berghei 
ProteomicsIsolation of mouse and human MHC class I- and II-associated peptides for the analysis of immunopeptidomes by mass spectrometry
Immunopeptidomics is an emerging field that fuels and guides the development of vaccines and immunotherapies. More specifically, it refers to the science of investigating the composition of peptides presented by major histocompatibility complex (MHC) class I and class II molecules using mass spectro...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-12-07 | PXD028633 | Pride
Mhc class i associated peptides Mass spectrometry Human Immunopeptidome Mhc class ii associated peptides Mouse 
TranscriptomicsTranscription profiling by array of human monocytes were cultured with DcR3 in the presence of M-CSF
Decoy receptor 3 (DcR3) is a member of the TNF receptor superfamily and is up-regulated in tumors that originate from a diversity of lineages. DcR3 is capable of promoting angiogenesis, inducing dendritic cell apoptosis, and modulating macrophage differentiation. Since tumor-associated macrophages (...
ORGANISM(S): Homo sapiens 
2008-04-05 | E-GEOD-10856 | biostudies-arrayexpress
ProteomicsChicken MHC class II presented Marek's disease virus (MDV) and infectious bursal disease virus (IBDV) antigenic peptides
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens. Unlike humans and other typical mammals, the major histocompatibility complex (MHC) of chickens can confer...
ORGANISM(S): Gallus gallus (Chicken) 
2021-09-10 | PXD023954 | Pride
Mdv Chicken mhc Immunopeptidomics Mhc class ii Ibdv Mhc class i 
ProteomicsStudy Samples Dendritic Cell MHC II presentation by LC-MSMS
MAPPs data was used to construct an artificial neural network (ANN) model for MHC class II antigen presentation. Using Infliximab and Rituximab, the model demonstrated an unprecedented performance for predicting MAPPs and CD4 T cell epitopes, complementing results from MAPPs assays and outperforming...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD018303 | Pride
Lc-msms Mhc-associated peptide proteomics (mapps) Mhc ii presentation Dendritic cells 
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