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TranscriptomicsMicroarray of MDV infected cultured chicken bursa cells
B lymphocytes from the chicken Bursa of Fabricius were isolated and cultured in the presence of CD40L. Cells were infected with a GFP fluorescent reporter virus of the very virulent Marek's disease virus (vvMDV) strain RB-1B (RB-1B_UL47-GFP, see doi: 10.1073/pnas.1424420112). After 24h viable infect...
ORGANISM(S): Gallus gallus 
2021-07-10 | E-MTAB-10702 | biostudies-arrayexpress
TranscriptomicsThe Transcriptional Landscape of Marek’s Disease Virus in Primary Chicken B Cells Reveals Novel Splice Variants and Genes
Marek's disease virus (MDV) belongs to the alphaherpesviruses and is the causative agent of fatal T cell lymphomas in chickens. Aftermaths of MDV infections lead to substantial losses in poultry industry and there is evidence that MDV constantly evolves towards higher virulence. This study takes a d...
ORGANISM(S): Gallus gallus 
2019-03-19 | E-MTAB-7772 | biostudies-arrayexpress
GenomicsHistone modifications induced by MDV infection at early cytolytic and latency phases
Background: Marek’s disease (MD) is a highly contagious, lymphomatous disease of chickens induced by a herpesvirus, Marek’s disease virus (MDV) that is the cause of major annual losses to the poultry industry. MD pathogenesis involves multiple stages including an early cytolytic phase and latency, a...
ORGANISM(S): Gallus gallus 
2015-04-17 | E-GEOD-65961 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken spleen and thymus infected Mareks disease virus (MDV) - a highly contagious oncogenic herpes virus
Marek's disease virus (MDV) is a highly contagious oncogenic herpes virus. Classed as an alpha herpes virus due to its DNA sequence and genome organization, its biological properties are more similar to those of gamma herpes viruses. MDV causes an initial cytolytic infection in B lymphocytes (3-6dpi...
ORGANISM(S): Gallus gallus 
2010-12-31 | E-TABM-721 | biostudies-arrayexpress
ProteomicsChicken MHC class II presented Marek's disease virus (MDV) and infectious bursal disease virus (IBDV) antigenic peptides
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens. Unlike humans and other typical mammals, the major histocompatibility complex (MHC) of chickens can confer...
ORGANISM(S): Gallus gallus (Chicken) 
2021-09-10 | PXD023954 | Pride
Mdv Chicken mhc Immunopeptidomics Mhc class ii Ibdv Mhc class i 
ProteomicsProteomic profiling of brain mitochondrial-derived vesicles
The generation of mitochondrial-derived vesicles (MDVs) is implicated in a plethora of vital cell functions, from mitochondrial quality control to peroxisomal biogenesis. The discovery of distinct subtypes of MDVs has revealed the selective inclusion of mitochondrial cargo in response to varying sti...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-07 | PXD020197 | Pride
Brain Timstof Mouse Lc-ms/ms 
TranscriptomicsChicken Spleen Tissues: MDV-infected vs non-infected in inbred lines 63, 72 & RCSM
Transcriptional profiling of chicken spleen tissues from Marek's disease virus (MDV) infected and non-infected control individuals from three inbred chicken lines 63, 72, RCSM with varying disease resistance characteristics. Line 63 is highly resistant; line 72 is highly susceptible; and line RCSM h...
ORGANISM(S): Gallus gallus 
2010-09-08 | E-GEOD-24017 | biostudies-arrayexpress
GenomicsChicken Macrophage RNAseq MDV Infected/Control
RNAseq of chicken macrophages from MDV susceptible and resistant chicken lines
PRJEB29321 | ENA
TranscriptomicsmicroRNA profiling in Marek's disease virus induced lymphoma and infected spleen by deep sequencing
To investigate specific miRNA expression profiles of Marek's disease virus (MDV)-infected samples, we performed deep sequencing for miRNAs in four small RNA libraries, including MDV-infected tumorous spleen, MD lymphoma from liver, and non-infected spleen and lymphocytes from controls. A total of 7....
ORGANISM(S): Gallus gallus 
2013-12-30 | E-GEOD-31349 | biostudies-arrayexpress
UnknownUS3 Serine/Threonine Protein Kinase from MDV-1, MDV-2, and HVT Differentially Regulate Viral Gene Expression and Replication.
Not available
S-EPMC8069862 | biostudies-literature
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