Sort   by:  
 Page size 
TranscriptomicsPBMC response to B. pertussis filamentous hemagglutinin stimulation in vitro
Filamentous hemagglutinin (FHA), Bordetella pertussis' key adhesin, is both present at the cell surface and released in the extracellular milieu. To comprehend the role free FHA plays in the pathogenic process, we analyzed the global transcriptional changes in human peripheral blood mononuclear cell...
ORGANISM(S): Homo sapiens 
2008-10-29 | E-GEOD-8802 | biostudies-arrayexpress
ProteomicsGlucosidase Alpha Neutral C Promotes Influenza Virus Replication by Inhibiting Proteosome-Dependent Degradation of Hemagglutinin
The H7N9 influenza virus poses a significant threat to human health, and the mechanism by which it infects humans remains incompletely understood. Our investigation has unveiled significant insights into the role of glucosidase alpha, neutral C (ganc) gene in human H7N9 infections. Through whole gen...
ORGANISM(S): Homo Sapiens 
2025-03-10 | PXD061732 |
ProteomicsCleavage of hemagglutinin from influenza A, at varying pH and over a twenty-four hour time period in the presence of cathepsin B, H and S
Pathogen-derived peptides presented by MHCII that are best able to activate cognate CD4+ T cells and initiate an adaptive immune response are termed immunodominant. The exact mechanisms and molecular determinants of antigen processing that contribute to immunodominance remain unclear. Recently, atte...
ORGANISM(S): Influenza A virus (A/New Caledonia/20-JY2/1999(H1N1)) 
2021-08-16 | PXD027327 | Pride
Mhcii Cathepsin Influenza a Immunodominance Hemagglutinin Lc-ms/ms 
ProteomicsHost-Switching Mutations in H5 Hemagglutinin Suppress Protein Dynamics at Activation pH
Increase in the occurrence and severity of human H5N1 spillover infections resulting from dissemination of highly pathogenic avian influenza (HPAI) virus into bird and mammal populations raises concerns about HPAI adapting to become human transmissible. Studies identified hemagglutinin acid stabilit...
ORGANISM(S): Homo sapiens (Human) 
2025-10-30 | PXD059353 | Pride
Hdx-ms 
TranscriptomicsSingle cell RNA-seq of hemagglutinin specific B cells after influenza virus infection: gene expression data
Understanding dynamics of antigen specific B cell responses and link between BCR and B cell differentiation is crucial for our ability to direct immune responses and to generate memory and plasma cells responses to protective targets. Here we have infected mice with IAV-PR8 and sacrificed them at di...
ORGANISM(S): Mus musculus 
2021-06-22 | E-MTAB-9491 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of hemagglutinin specific B cells after influenza virus infection: VDJ data
Understanding dynamics of antigen specific B cell responses and link between BCR and B cell differentiation is crucial for our ability to direct immune responses and to generate memory and plasma cells responses to protective targets. Here we have infected mice with IAV-PR8 and sacrificed them at di...
ORGANISM(S): Mus musculus 
2021-06-22 | E-MTAB-9478 | biostudies-arrayexpress
ProteomicsDeciphering and predicting CD4+ T cell immunodominance of Influenza virus hemagglutinin
The importance of CD4+ T helper (Th) cells is well appreciated in view of their essential role in the elicitation of antibody and cytotoxic T cell responses. However, the mechanisms that determine the selection of immunodominant epitopes within complex protein antigens remain elusive. Here, we used ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Influenza A virus (A/California/07-00002/2009(H1N1)) 
2020-06-29 | PXD018151 | Pride
Peptidomics Influenza Mhc-ii Modc Ebv-b Antigen presentation Human Hemagglutinin 
ProteomicsPlant-derived virus-like particle vaccines drive cross-presentation of influenza A hemagglutinin peptides by human monocyte-derived macrophages
A growing body of evidence supports the importance of T cell responses to protect against severe influenza, promote viral clearance and ensure long-term immunity. Plant-derived virus-like particle (VLP) vaccines bearing influenza hemagglutinin (HA) have been shown to elicit strong humoral and CD4+ T...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD010519 | Pride
Influenza Cell-mediated immunity Cross-presentation Major histocompatibility complex class i Human monocyte-derived macrophage High-resolution mass spectrometry Plant-derived vaccine Virus-like particle 
ProteomicsLongitudinal proteomic analysis of influenza HA-reactive IgG antibody repertoire over multiple years and repeated vaccinations
Longitudinal proteomic analysis of H1N1 A/California/7/2009 (CA09) hemagglutinin (HA)-reactive serum IgG antibody repertoire over 5 years and multiple (yearly) vaccinations (both pre- and post-vaccination samples) in a donor. Dataset consists of steady-state (pre-vaccination at day 0) and peak-respo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-08 | MSV000083120 | MassIVE
GenomicsSequencing of the influenza PR8 virus hemagglutinin Sb site mutant library
Sequencing of the influenza PR8 virus hemagglutinin Sb site mutant library
PRJNA1061508 | ENA
Sort   by:  
 Page size