Sort   by:  
 Page size 
GenomicsCatchet-MS identifies IKZF1-targeting Thalidomide analogues as novel HIV-1 latency reversal agents
Catchet-MS identifies IKZF1-targeting Thalidomide analogues as novel HIV-1 latency reversal agents
PRJNA803185 | ENA
GenomicsCatchet-MS identifies IKZF1-targeting Thalidomide analogues as novel HIV-1 latency reversal agents
A major pharmacological strategy toward HIV cure aims to reverse latency in infected cells as a first step leading to their elimination. While the unbiased identification of molecular targets physically associated with the latent HIV-1 provirus would be highly valuable to unravel the molecular deter...
ORGANISM(S): Homo sapiens 
2022-02-06 | GSE196059 | GEO
UnknownCatchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents.
Not available
S-EPMC9177988 | biostudies-literature
ProteomicsdCas9 targeted chromatin and histone enrichment for mass spectrometry (Catchet-MS) identifies IKZF1 as a novel target for HIV-1 latency reversal
HIV-1 infected patients virally suppressed by antiviral treatment harbor a persistent reservoir of replication competent latent HIV-1 infected cells, which constitute the main roadblock to a cure. A main strategy for HIV cure aims to stimulate viral gene expression in latently infected cells so that...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD032975 | Pride
Catchet-ms Ikzf1 Hiv-1 latency reversal 
TranscriptomicsPCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency
HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. To elucidate the molecular players that govern latency, we previously performed a dCas9-chromatin immunoprecipitation coupled with mass spectrometry (Catchet-MS) and identified the i...
ORGANISM(S): Homo sapiens 
2023-12-10 | GSE249455 | GEO
ProteomicsPCID2 regulates HIV-1 transcription and viral RNA processing during latency
HIV-1 latency results from a combination of tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. In an effort to elucidate the molecular players that govern viral latency, we previously performed a dCas9 chromatin immunoprecipitation coupled with mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043334 | Pride
Pcid2 regulates hiv-1 transcription and viral rna processing during latency 
GenomicsPCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency
PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency
PRJNA1049312 | ENA
Sort   by:  
 Page size