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MetabolomicsLysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have indicated a potential relationship between lysosomes and eosinophils, the precise role of lysosomes in eosinophil acti...

2025-09-15 | MTBLS13001 | MetaboLights
ProteomicsMSP-MS of Cathepsin B and Cathepsin K pH 4.6 pH 7.2
MSP-MS of Cathepsin B and Cathepsin K pH 4.6 pH 7.2
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2022-02-28 | MSV000088932 | MassIVE
ProteomicsMSP-MS of Cathepsin L and Cathepsin V pH 5.5
MSP-MS of Cathepsin L and Cathepsin V pH 5.5 at 37C
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
MSV000088091 | MassIVE
ProteomicsCathepsin B MSP-MS at pH 4.6 and pH 7.2
MSP-MS of Cathepsin B protease at acidic and neutral pH
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2020-11-12 | MSV000086447 | MassIVE
ProteomicsCathepsin B MSP-MS at pH 4.6 and 7.2 without inhibitor
MSP-MS of Cathepsin B at pH 4.6 and pH 7.2 without inhibitor
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2020-11-12 | MSV000086449 | MassIVE
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
TranscriptomicsAdenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic regulation of RNA metabolism. However, the role of A-to-I RNA editing in vascular disease is unknown. Here we show that cathepsin S mRN...
ORGANISM(S): Homo sapiens 
2016-09-05 | E-GEOD-60217 | biostudies-arrayexpress
ProteomicsImpact of cathepsin A on the murine cardiac proteome
Cathepsin A (CTSA) is a lysosomal carboxypeptidase present at the cell surface and secreted outside the cell. Additionally, CTSA binds to β-galactosidase and neuraminidase 1 to protect them from degradation. CTSA has gained attention as a drug target for the treatment of cardiac hypertrophy and hear...
ORGANISM(S): Mus musculus (Mouse) 
2016-07-25 | PXD003860 | Pride
Transgenic mouse Cathepsin a Lc-ms/ms 
ProteomicsPotent anti-SARS-CoV-2 activity by the natural product gallinamide A and analogues via inhibition of cathepsin L
The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a key host cysteine protease utilized b...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027300 | Pride
Mrc5 Sars-cov-2 Covid Cathepsin l Veroe6 Gallinamide a Hek293 
ProteomicsCathepsin B and Cathepsin Z tumor secretome of murine breast cancers
MS-based proteomics study of the cancer secretome and tumor interstitial fluid of tumor cell/macrophage co-cultures and breast tumors in cells and mice lacking both cathepsin B and cathepsin Z
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015209 | Pride
Tumor interstitial fluid Ccm Mouse Secretome 
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