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MetabolomicsLysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have indicated a potential relationship between lysosomes and eosinophils, the precise role of lysosomes in eosinophil acti...

2025-09-15 | MTBLS13001 | MetaboLights
ProteomicsMSP-MS of Cathepsin L and Cathepsin V pH 5.5
MSP-MS of Cathepsin L and Cathepsin V pH 5.5 at 37C
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
MSV000088091 | MassIVE
ProteomicsMSP-MS of Cathepsin B and Cathepsin K pH 4.6 pH 7.2
MSP-MS of Cathepsin B and Cathepsin K pH 4.6 pH 7.2
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2022-02-28 | MSV000088932 | MassIVE
ProteomicsCathepsin B MSP-MS at pH 4.6 and pH 7.2
MSP-MS of Cathepsin B protease at acidic and neutral pH
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2020-11-12 | MSV000086447 | MassIVE
ProteomicsCathepsin B MSP-MS at pH 4.6 and 7.2 without inhibitor
MSP-MS of Cathepsin B at pH 4.6 and pH 7.2 without inhibitor
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2020-11-12 | MSV000086449 | MassIVE
ProteomicsPotent anti-SARS-CoV-2 activity by the natural product gallinamide A and analogues via inhibition of cathepsin L
The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a key host cysteine protease utilized b...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027300 | Pride
Mrc5 Sars-cov-2 Covid Cathepsin l Veroe6 Gallinamide a Hek293 
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse expressing human Cathepsin L inhibitor hurpin, skin alterations and increased carcinogenesis.
Aim of this study was to identify gene expression differences in the skin of hurpin (=headpin=serpinB13) transgenic mice in comparison to wildtype mice. Experiment Overall Design: Comparison of 4 transgenic mice with 3 wildtype mice. One wildtye sample was used two times. Experiment Overall Design:...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5236 | biostudies-arrayexpress
ProteomicsCathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation
Rapidly proliferating cells reshape their metabolism to satisfy their ever-lasting need for building blocks. This phenomenon is exemplified in certain malignant conditions but also occurs during embryonic development, when cells rely heavily on glycolytic metabolism to exploit their metabolic interm...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-06 | PXD011588 | Pride
Abpp Cathepsin l Cell growth proliferation 
TranscriptomicsAdenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic regulation of RNA metabolism. However, the role of A-to-I RNA editing in vascular disease is unknown. Here we show that cathepsin S mRN...
ORGANISM(S): Homo sapiens 
2016-09-05 | E-GEOD-60217 | biostudies-arrayexpress
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