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MetabolomicsSeipin Governs Caveolin-1 Trafficking Through Modulating Sphingolipid-Glycerolipid Balance

Dysregulation of Caveolin-1 (CAV1), a key component of caveolae, leads to pleiotropic disorders; yet, the mechanisms controlling its trafficking remain unclear. Here, we show that the lipid droplet (LD) biogenesis factor seipin controls CAV1 localization. Seipin deficiency in mice and HeLa cells ...

2025-07-22 | MTBLS12759 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
ProteomicsLipid-induced Caveolin1-Lipid droplet trafficking is needed for lipid droplet growth
Caveolae are 50-100 nm sized plasma membrane invaginations that were previously related to cellular lipid uptake and lipid accumulation. Several caveolin1 and cavin1 mutations are associated to human lipodystrophy. However, currently is not understood how caveolae facilitate the lipid uptake, how in...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-23 | PXD069518 | Pride
Lipid Droplet Caveolin1 Dia Trafficking 
UnknownHomotrimer cavin1 interacts with caveolin1 to facilitate tumor growth and activate microglia through extracellular vesicles in glioma.
Not available
S-EPMC7295042 | biostudies-literature
GenomicsCaveolin1 and YAP drive mechanically-induced mesothelial-to-mesenchymal transition and fibrosis
Caveolin1 and YAP drive mechanically-induced mesothelial-to-mesenchymal transition and fibrosis
PRJNA612495 | ENA
GenomicsCaveolin1 Deficiency: A Type I Endothelial Interferonopathy Associated with Pulmonary Arterial Hypertension
Caveolin1 Deficiency: A Type I Endothelial Interferonopathy Associated with Pulmonary Arterial Hypertension
PRJNA577943 | ENA
UnknownEstrogen Induces Selective Transcription of Caveolin1 Variants in Human Breast Cancer through Estrogen Responsive Element-Dependent Mechanisms.
Not available
S-EPMC7503496 | biostudies-literature
UnknownImpairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1.
Not available
S-EPMC3613184 | biostudies-literature
UnknownGlycocalyx is critical for blood-brain barrier integrity by suppressing caveolin1-dependent endothelial transcytosis following ischemic stroke.
Not available
S-EPMC8713524 | biostudies-literature
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