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MetabolomicsATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth

Lipid droplet (LD) growth mechanisms and the roles of LD-associated lipid transfer proteins remain poorly understood. Here, we show that the autophagy lipid transfer protein ATG2A has an anabolic role and promotes LD expansion by transferring diacylglycerol (DAG), and potentially triacylglycerol ...

2025-09-07 | MTBLS12951 | MetaboLights
MetabolomicsLipid Droplet Inhibitors for Disrupting Lipid Accumulation in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Excessive lipid droplet accumulation in hepatocytes drives the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), often leading to inflammation and fibrosis. As obesity and metabolic syndrome rise, MASLD has become a global concern, spurring research into effective trea...
2025-07-17 | MTBLS12359 | MetaboLights
MetabolomicsRetromer mediates Ypt7-dependent lipid droplet internalization

Lipid droplets (LDs) are dynamic organelles central to cellular energy homeostasis and stress adaptation. Maintaining LD balance is critical for cell function, yet the mechanisms governing selective LD degradation remain unclear. Here, we reveal a pathway promoting efficient vacuolar sequestering...

2026-07-15 | MTBLS15038 | MetaboLights
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
ProteomicsIdentification of a lipid droplet-plasma membrane tethering complex
Membrane contact sites (MCS) are interorganellar contacts that allow for the direct exchange of molecules such as lipids or Ca2+ between organelles, but can also be a mean for tethering of organelles. In mammals and yeast, LDs have been shown to engage in MCS with nearly all organelles in the cell, ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-06-09 | PXD022769 | Pride
Seedling Membrane contact sites Arabidopsis Tag Tethering complex Seed Lipid droplets Germination Plasma membrane 
Genomicsdroplet culture
droplet culture Raw sequence reads
PRJNA1132697 | ENA
ProteomicsTurboID-based proximity labeling of ER-localized TMEM120A/B interactome in Oleic Acid-treated HEK293T cells
Raw mass spectrometry data (.d raw data from Bruker) supporting the study: "A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis". This dataset contains LC-MS/MS raw files from a proximity labeling experiment (TurboID) designed to identify interacting ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD075982 | Pride
Proximity labeling Turboid Tag Lipid droplet 
TranscriptomicsDroplet barcoding for single cell transcriptomics applied to embryonic stem cells
Recently, RNA sequencing has achieved single cell resolution, but what is limiting is an effective way to routinely isolate and process large numbers of individual cells for in-depth sequencing, and to do so quantitatively. We have developed a droplet-microfluidic approach for parallel barcoding tho...
ORGANISM(S): Homo sapiens 
2015-05-20 | E-GEOD-65525 | biostudies-arrayexpress
ProteomicsCLSTN3B promotes lipid droplet maturation and lipid storage in adipocytes
LUM1_969842: Brown adipocyte lipid droplet proteomics (Figure 4d): 126, 127N, 127C, 128N: WT 128C, 129N, 129C, 130N: KO (clstn3b-/-) LUM1_997681: White adipocyte lipid droplet proteomics (Figure 4e): 126, 127C, 127N, 128C, 128N: WT 129C, 129N, 130C, 130N, 131N: KO (clstn3b-/-)
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000095763 | MassIVE
ProteomicsThe lipid droplet protein DHRS3 is a regulator of melanoma cell state
Lipid droplets are fat storage organelles composed of a protein envelope which surrounds a lipid rich core. Dynamic regulation of this protein envelope underlies differential lipid droplet formation and function in diverse cell types. In melanoma, the ability to form lipid droplets has been linked t...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD050693 | Pride
Lipid droplet Dhrs3 Melanoma Human 
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