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GenomicsMolecular Signatures of CB-6644 inhibition of the RUVBL1/2 complex in Multiple Myeloma [RNA-seq]
Molecular Signatures of CB-6644 inhibition of the RUVBL1/2 complex in Multiple Myeloma [RNA-seq]
PRJNA1133724 | ENA
GenomicsMolecular Signatures of CB-6644 inhibition of the RUVBL1/2 complex in Multiple Myeloma [ATAC-seq]
Molecular Signatures of CB-6644 inhibition of the RUVBL1/2 complex in Multiple Myeloma [ATAC-seq]
PRJNA1133720 | ENA
UnknownMolecular Signatures of CB-6644 Inhibition of the RUVBL1/2 Complex in Multiple Myeloma.
Not available
S-EPMC11354775 | biostudies-literature
TranscriptomicsMolecular Signatures of CB-6644 inhibition of the RUVBL1/2 complex in Multiple Myeloma [RNA-seq]
Multiple Myeloma is the second most hematological cancer. RUVBL1 and RUVBL2 forms a subcomplex of many chromatin remodeling complexes implicated in cancer progress. As an inhibitor specific to the RUVBL1/2 complex, CB-6644 exhibits remarkable anti-tumor activity in xenograft models of Burkitt’s lymp...
ORGANISM(S): Homo sapiens 
2024-08-19 | GSE271840 | GEO
GenomicsMolecular Signatures of CB-6644 inhibition of the RUVBL1/2 complex in Multiple Myeloma [ATAC-seq]
Multiple Myeloma is the second most hematological cancer. RUVBL1 and RUVBL2 forms a subcomplex of many chromatin remodeling complexes implicated in cancer progress. As an inhibitor specific to the RUVBL1/2 complex, CB-6644 exhibits remarkable anti-tumor activity in xenograft models of Burkitt’s lymp...
ORGANISM(S): Homo sapiens 
2024-08-19 | GSE271838 | GEO
Genomics
Effect of RUVBL1/2 inhibitor (CB-6644) on proinflammatory gene expressions in RAW 264.7 cells
PRJNA698449 | ENA
ProteomicsTargeting RuvBL1 disrupts mitochondrial metabolism and structure in hepatocellular carcinoma
Huh7 cells endogenously tagged with OMP25HA and OMP25MYC were treated with the RuvBL1/2 small molecule inhibitor CB-6644 (1uM for 48h. Mitochondria were immunoprecipitated with anti-HA magnetic beads. OMP25MYC-tagged mitochondria served as negative control for IP.
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD075574 | Pride
Atpsynthase Hcc Ruvbl1 Mitochondria Huh7 Cb-6644 
TranscriptomicsRUVBL1 and RUVBL2 as novel druggable DNA Damage Response regulators in the MYCN regulatory network in neuroblastoma
To understand its role RUVBL1/2 in neuroblastoma, we inhibited RUVBL1/2 ATPase activity two independent cell lines, SK-N-AS and CBL-BA, with 250 nM CB-6644 at 0, 24, 48, and 72 hrs and performed RNA sequencing.
ORGANISM(S): Homo sapiens 
2024-08-31 | E-MTAB-13137 | biostudies-arrayexpress
GenomicsRUVBL1 and RUVBL2 are druggable MYCN regulators in neuroblastoma
High-risk neuroblastoma (NB), accounting for approximately 50% of all cases, exhibits high relapse rates and life-threatening toxicities despite intensive therapies, highlighting the need for safer and more effective treatments. Analysis of publicly available NB transcriptomic datasets identified RU...
ORGANISM(S): Homo sapiens 
2025-12-22 | GSE312769 | GEO
GenomicsRUVBL1 and RUVBL2 as novel druggable DNA Damage Response regulators in the MYCN regulatory network in neuroblastoma
RUVBL1 and RUVBL2 as novel druggable DNA Damage Response regulators in the MYCN regulatory network in neuroblastoma
PRJEB63991 | ENA
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