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ProteomicsImmunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia
Bacterial lytic polysaccharide monooxygenases (LPMOs) are understudied in the context of infection disease. We demonstrated that Pseudomonas aeruginosa LPMO CbpD is a virulence determinant in pneumonia. Moreover, Mice immunized with CbpD generate robust antibody responses that provide protection aga...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-26 | PXD039298 | Pride
Cbpd Lpmo Pnemonia Pseudomonas aeruginosa 
UnknownThe lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection.
Not available
S-EPMC7902821 | biostudies-literature
ProteomicsThe lytic polysaccharide monooxygenase of Pseudomonas aeruginosa promotes bacterial survival during systemic infection
Lytic polysaccharide monooxygenases (LPMOs) are a recently discovered enzyme family that cleave polysaccharides by oxidation. Despite proposed roles in bacterial virulence, no direct functional data exist to validate these claims. Here we show that CpbD, the LPMO of the opportunistic pathogen Pseudo...
ORGANISM(S): Pseudomonas aeruginosa 
2021-01-28 | PXD021888 | Pride
Cbpd Secretome Pellet 
UnknownThe crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases.
Not available
S-EPMC9344471 | biostudies-literature
UnknownImmunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia.
Not available
S-EPMC10372616 | biostudies-literature
UnknownCholine-binding protein D (CbpD) in Streptococcus pneumoniae is essential for competence-induced cell lysis.
Not available
S-EPMC1151764 | biostudies-literature
ProteomicsThe lytic polysaccharide monooxygenase of Pseudomonas aeruginosa promotes bacterial survival during systemic infection
Lytic polysaccharide monooxygenases (LPMOs) are a recently discovered enzyme family that cleave polysaccharides by oxidation. Despite proposed roles in bacterial virulence, no direct functional data exist to validate these claims. Here we show that CpbD, the LPMO of the opportunistic pathogen Pseudo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Pseudomonas aeruginosa 
2021-01-28 | PXD017971 | Pride
Lpmo Virulence Mice Pseudomonas aeruginosa Spleen 
UnknownLytF, a novel competence-regulated murein hydrolase in the genus Streptococcus.
Not available
S-EPMC3264080 | biostudies-literature
UnknownCompetence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence.
Not available
S-EPMC9910801 | biostudies-literature
ProteomicsTargeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
Prostate cancer is driven by oncogenic transcription factor enhanceosomes comprising chromatin and epigenetic regulators. The lysine acetyltransferases p300 and CBP are key cofactors that activate enhancers through histone acetylation. Here, we identify p300/CBP-mediated multisite acetylation of the...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD065228 | Pride
Prostate cancer Protac degrader cbpd-409 P300/cbp 
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