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TranscriptomicsHP1, H3-K27me3, and H3-K9me3 Cut & Tag of Het (Cbx1+/+, Cbx3+/+, Cbx5+/-) and TKO (Cbx1-/-, Cbx3-/-, Cbx5-/-) bipotential mouse embryonic liver (BMEL) cells
Cut & Tag was used to localize the 3 mouse HP1 proteins (Cbx1,Cbx3,Cbx5) to the genome of BMEL (bipotential mouse embryonic liver) cells. Het BMEL cells are Cbx1+/+, Cbx3+/+, Cbx5+/- HP1-TKO (triple knock-out cells) are Cbx1-/-, Cbx3-/-, Cbx5-/-. The HP1_TKO cells were used to verify the specificity...
ORGANISM(S): Mus musculus 
2025-06-14 | E-MTAB-15189 | biostudies-arrayexpress
TranscriptomicsNetwork Biology of Tumor Stem-like Cells Identified a Regulatory Role of CBX5 in Lung Cancer
Mounting evidence points to a link between a cancer possessing stem-like properties and a worse prognosis. To understand the biology, a common approach is to integrate network biology with signal processing mechanics. That said, even with the right tools, predicting the risk for a highly susceptible...
ORGANISM(S): Homo sapiens 
2012-08-17 | E-GEOD-35603 | biostudies-arrayexpress
GenomicsHP1, H3-K27me3, and H3-K9me3 Cut & Tag of Het (Cbx1+/+, Cbx3+/+, Cbx5+/-) and TKO (Cbx1-/-, Cbx3-/-, Cbx5-/-) bipotential mouse embryonic liver (BMEL) cells
HP1, H3-K27me3, and H3-K9me3 Cut & Tag of Het (Cbx1+/+, Cbx3+/+, Cbx5+/-) and TKO (Cbx1-/-, Cbx3-/-, Cbx5-/-) bipotential mouse embryonic liver (BMEL) cells
PRJEB90041 | ENA
GenomicsTargeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis
Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis
PRJNA1013126 | ENA
GenomicsAnalysis of open chromatin structures in HCC827 CBX5 knockdown cells by ATAC seq analysis .
Analysis of open chromatin structures in HCC827 CBX5 knockdown cells by ATAC seq analysis .
PRJNA702835 | ENA
TranscriptomicsBRD4 represses CBX5
BRD4 is amplified and/or up-regiulated in a subset of ovarian cancer which correlates with a poor survival siRNA sensitization screens in the presence of CHK1 inhibitor, LY2606368, identify BRD4 as a therapeutic target in ovarian cancer. BRD4 suppression by either siRNA or using JQ1 increases CBX5 e...
ORGANISM(S): Homo sapiens 
2016-05-01 | GSE78704 | GEO
UnknownTargeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis.
Not available
S-EPMC12143411 | biostudies-literature
UnknownCBX5 loss drives EGFR inhibitor resistance and results in therapeutically actionable vulnerabilities in lung cancer.
Not available
S-EPMC9942844 | biostudies-literature
UnknownBRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1).
Not available
S-EPMC5584257 | biostudies-literature
TranscriptomicsTargeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis
Idiopathic pulmonary fibrosis (IPF) is characterized by the sustained activation of interstitial fibroblasts leading to excessive collagen deposition and progressive organ failure. Epigenetic and metabolic abnormalities have been shown to contribute to the persistent activated state of scar-forming ...
ORGANISM(S): Homo sapiens 
2025-06-16 | GSE242408 | GEO
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