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ProteomicsMechanical compression reduces CC16 expression and disrupts metabolic homeostasis in airway epithelial cells
Recent evidence suggests that bronchial epithelial cells from asthmatic patients exhibit altered metabolic signatures. This metabolic shift of energetically demanding cells leads to increased inflammation, excessive reactive oxygen species production (ROS), and oxidative stress—all hallmarks of mito...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-05-25 | PXD067703 | Pride
Cc16 Mitochondria Asthma 
ProteomicsCC16 drives VLA-2-dependent SPLUNC1 expression.
Rationale: CC16 (Club Cell Secretory Protein) is a protein produced by club cells and other non-ciliated epithelial cells within the lungs. CC16 has been shown to protect against the development of obstructive lung diseases and attenuate pulmonary pathogen burden. Despite recent advances in understa...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-13 | PXD046830 | Pride
Short palate lung and nasal epithelial clone 1 Club cell secretory protein Epithelial-driven host responses 
UnknownCC16 augmentation reduces exaggerated COPD-like disease in Cc16-deficient mice.
Not available
S-EPMC10070105 | biostudies-literature
UnknownCC16 drives VLA-2-dependent SPLUNC1 expression.
Not available
S-EPMC10694244 | biostudies-literature
UnknownRepression of CC16 by cigarette smoke (CS) exposure.
Not available
S-EPMC4312097 | biostudies-literature
UnknownProtective role for club cell secretory protein-16 (CC16) in the development of COPD.
Not available
S-EPMC4451404 | biostudies-literature
UnknownRelationships of serum CC16 levels with smoking status and lung function in COPD.
Not available
S-EPMC9479424 | biostudies-literature
UnknownUrinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis.
Not available
S-EPMC7167874 | biostudies-literature
UnknownEffects of obesity on CC16 and their potential role in overweight/obese asthma.
Not available
S-EPMC9241210 | biostudies-literature
UnknownCC16 Levels into Adult Life Are Associated with Nitrogen Dioxide Exposure at Birth.
Not available
S-EPMC6727155 | biostudies-literature
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