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GenomicsER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability
ER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability
PRJNA1263720 | ENA
ProteomicsIdentification of potential CCDC134 interactors by immunoprecipitation and LC-MS analysis
Our data indicate that CCDC134 plays a critical role in regulating the biogenesis of Toll-like receptors (TLRs). To gain deeper insights into the molecular mechanisms through which CCDC134 mediates TLR regulation, we sought to identify potential binding partners using interaction proteomics. Mass sp...
ORGANISM(S): Homo sapiens (Human) 
2024-11-14 | PXD053008 | Pride
Ccdc134 Immunoprecipitation Cal-1 
ProteomicsFull proteome analysis of Hoxb8 immortalized murine myeloid progenitors knockout for CCDC134 and differentiated into macrophages
We recently identified CCDC134 as a novel regulator of TLR responses. To gain a comprehensive understanding of the effects of CCDC134 loss, we conducted total proteome analysis on control sgRen and sgCCDC134 Hoxb8 immortalized murine myeloid progenitors that were differentiated into macrophages. Int...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-14 | PXD053042 | Pride
Ccdc134 Full proteome Hoxb8 macrophages 
TranscriptomicsER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability
Toll-like receptor 4 (TLR4), a pattern-recognition receptor located on the plasma membrane, senses extracellular danger signals to initiate inflammatory immune responses. It is initially synthesized in the endoplasmic reticulum (ER), undergoes N-linked glycosylation, and is subsequently transported ...
ORGANISM(S): Mus musculus 
2025-08-01 | GSE297380 | GEO
UnknownCCDC134 controls TLR biogenesis through the ER chaperone Gp96.
Not available
S-EPMC11629888 | biostudies-literature
UnknownER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability.
Not available
S-EPMC12403076 | biostudies-literature
UnknownCCDC134 as a Prognostic-Related Biomarker in Breast Cancer Correlating With Immune Infiltrates.
Not available
S-EPMC8927640 | biostudies-literature
UnknownCCDC134 facilitates T cell activation through the regulation of early T cell receptor signaling.
Not available
S-EPMC10206301 | biostudies-literature
UnknownFetal Fractures in an Infant with Maternal Ehlers-Danlos Syndrome, CCDC134 Pathogenic Mutation and a Negative Genetic Test for Osteogenesis Imperfecta.
Not available
S-EPMC8235512 | biostudies-literature
OtherStructural basis of regulated N-glycosylation at the secretory translocon
Most human secretory pathway proteins are N-glycosylated by oligosaccharyltransferase complexes as they enter the endoplasmic reticulum. Recent work revealed a substrate-assisted mechanism by which N-glycosylation of the chaperone GRP94 is regulated to control cell surface receptor signaling. Here w...
ORGANISM(S): Homo sapiens 
2025-09-27 | GSE303507 | GEO
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