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GenomicsRNA-seq analysis of CD276-high/EpCAM+ cells from HNSCC patient-derived-xenograft
RNA-seq analysis of CD276-high/EpCAM+ cells from HNSCC patient-derived-xenograft
PRJNA548543 | ENA
TranscriptomicsRNA-seq analysis of CD276-high/EpCAM+ cells from HNSCC patient-derived-xenograft
We performed RNA sequencing (RNA-seq) to compare the gene expression pattern between CD276-high/EpCAM+ and CD276-low/EpCAM+ cells isolated from human HNSCC PDX. We identified a cohort of key oncogenes associate with cancer stemness enriched in CD276-high cells. Suggesting CD276 may play a positive r...
ORGANISM(S): Homo sapiens 
2021-05-28 | GSE132627 | GEO
GenomicsCD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1
CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1
PRJNA695207 | ENA
TranscriptomicsCD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1
70-100% of colorectal, prostate, ovarian, pancreatic and breast cancer specimens show expression of CD276 (B7-H3), a potential immune checkpoint family member. Several studies have shown that high CD276 expression in cancer cells correlates with a poor clinical prognosis. This has been associated wi...
ORGANISM(S): Homo sapiens 
2021-07-28 | GSE165610 | GEO
UnknownTargeting CD276 with Adapter-CAR T-cells provides a novel therapeutic strategy in small cell lung cancer and prevents CD276-dependent fratricide.
Not available
S-EPMC12305915 | biostudies-literature
UnknownCD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models.
Not available
S-EPMC10625270 | biostudies-literature
UnknownSilencing of CD276 suppresses lung cancer progression by regulating integrin signaling.
Not available
S-EPMC7330387 | biostudies-literature
UnknownCD276 as a Candidate Target for Immunotherapy in Medullary Thyroid Cancer.
Not available
S-EPMC10298428 | biostudies-literature
UnknownGlutamine transporter SLC1A5 inhibits autophagy-mediated CD276 degradation to promote esophageal cancer progression.
Not available
S-EPMC12867364 | biostudies-literature
ProteomicsLateral interactions between B7-H3 and CD147 are essential for stemness in breast cancer: a novel insight from proximal proteome analysis
Oncogenic cell-surface membrane proteins contribute to the phenotypic and functional characteristics of cancer stem cells (CSCs). We quantitatively analyzed cell-surface membrane proteins that are in close proximity to CD147 in CSCs using proximity-labeling proteomic approach. Moreover, we compared ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036909 | Pride
Proximal proteome analysis Breast cancer Cancer stem cells Drug resistance Cd276 Lipid raft Protein-protein interaction Cd147 
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