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TranscriptomicsThe comparison of CpG methylation profiles between CD34+ and CD34- human umbilical cord blood cells
Evidence for the epigenetic regulation of hematopoietic stem cells (HSCs) is growing, but the genome-wide epigenetic signature of HSCs and its functional significance remain unclear. In this study, we used high-resolition (Agilent, CpG Island ChIP-on-chip) platforms for genome-wide comparison of CpG...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-17833 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of Imatinib resistance in CD34+ cell populations from chronic myeloid leukaemia patients using Agilent-014698 Whole Human Genome 105K microarrays.
To ascertain genomic alterations associated with Imatinib resistance in chronic myeloid leukaemia, we performed high resolution genomic analysis of CD34+ cells from 25 Imatinib (IM) resistant and 11 responders CML patients. Using patients' T-cells as reference, we found significant association betwe...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-21986 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML
Mononuclear cells from AML patients (n=46) were sorted into CD34+ and CD34- subfractions and genome-wide expression analysis was performed using Illumina BeadChip Arrays (HT12 v3). Of 2 AML samples only the CD34+ fraction could be analyzed. AML CD34+ and CD34- gene expression was compared to a large...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-30029 | biostudies-arrayexpress
TranscriptomicsCombined miRNA and mRNA analysis of CD133(+) and CD34(+) cells
Microarray and miRNA analysis of CD133(+), CD34(+)CD133(-) and CD133(-)CD34(-) cells The goal of the experiment was the comparison of expression levels of mRNA and miRNA in CD133(+) and CD34(+)CD133(-) cells The RNA of CD133(+), CD34(+)CD133(-) and CD133(-)CD34(-) bone marrow cells was amplified by ...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-22460 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1)
Human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1).
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2049 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human bone marrow and peripheral blood CD34+ myeloblasts in acute myeloid leukaemia
To examine the differences between bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34+ myeloblasts of paired BM and peripheral blood (PB) samples from AML patients using microarray. Experiment Overall Design: 5 paired BM and PB leukaemic samples...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12326 | biostudies-arrayexpress
TranscriptomicsChronic myelogenous leukemia hematopoietic stem cells
We show the molecular and functional characterization of a novel population of lineage-negative CD34-negative (Lin- CD34-) hematopoietic stem cells (HSCs) from chronic myelogenous leukemia (CML) patients at diagnosis. Molecular caryotyping and quantitative analysis of BCR/ABL transcript demonstrated...
ORGANISM(S): Homo sapiens 
2010-01-04 | E-GEOD-11675 | biostudies-arrayexpress
TranscriptomicsIntegrative Analysis of Gene and miRNA expression profiles in Primary Myelofibrosis CD34+ cells
Ph-negative myeloproliferative neoplasms (MPNs) are characterized by many somatic mutations which have already been shown useful in the prognostic assessment of MPN patients. Moreover, aberrant microRNA (miRNA) expression seems to add to the molecular complexity of MPNs, as specific miRNA signatures...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-53482 | biostudies-arrayexpress
TranscriptomicsRNA expression profiles in CD34+ and in stromal cells of patients with refractory anemia with ringed sideroblasts
Myelodysplastic syndromes (MDS) are a group of clonal hematological disorders characterized by ineffective hematopoiesis with morphological evidence of marrow cell dysplasia resulting in peripheral blood cytopenia. Microarray technology has permitted a refined high-throughput mapping of the transcri...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-18911 | biostudies-arrayexpress
TranscriptomicsExpression data from human CD34+ HPC subpopulations isolated from umbilical cord blood (Haddad et al. Blood 104:3918, 2004)
We used microarrays to analyze the gene expression profile of CD34+CD45RA+CD7+, CD34+CD45RA+CD10+CD19- and CD34+CD45+CD7-CD10-CD19- HPCs isolated from umbilical cord blood CD34+CD45RA+CD7+(CD10-) and CD34+CD45RA+CD10+(CD7-CD19-) HPCs correspond respectively to prothymocytes and early pre-proB precur...
ORGANISM(S): Homo sapiens 
2011-05-25 | E-GEOD-29522 | biostudies-arrayexpress
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