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ProteomicsCD47 blocking antibody confers metabolic protective effects by promoting AMPK activation in skeletal muscle
Our study investigated the impact of CD47 gene deletion on protein acetylation and its regulatory effects on mitochondrial metabolism and function in the skeletal muscle of mice.
ORGANISM(S): Mus musculus (Mouse) 
2025-02-27 | PXD061117 | Pride
Cd47 blocking antibody Ampk Skeletal muscle Mitochondrial energetic 
ProteomicsN-terminal pyroglutamate in CD47 is involved in SIRPα interactions
T-cell immune checkpoint inhibitors have revolutionized cancer immunotherapy. In addition to T cells, immune checkpoint molecules have also been described for myeloid cells, with CD47 on tumor cells and Signal Regulatory Protein α (SIRPα) on effector cells being the most established example (Maute e...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2026-05-19 | PXD066444 | Pride
Pglu Therapeutic antibodies Cd47 Signal regulatory protein α (sirpα) Glutaminyl-peptide cyclotransferase-like (qpctl) 
UnknownCD47-blocking antibody confers metabolic benefits against obesity.
Not available
S-EPMC12147847 | biostudies-literature
UnknownA fully human anti-CD47 blocking antibody with therapeutic potential for cancer.
Not available
S-EPMC5347751 | biostudies-literature
GenomicsCD47 blocking antibody confers exercise effects by activating AMPK and improving mitochondrial energetics of skeletal muscle
CD47 blocking antibody confers exercise effects by activating AMPK and improving mitochondrial energetics of skeletal muscle
PRJNA773074 | ENA
UnknownCD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage.
Not available
S-EPMC8197745 | biostudies-literature
GenomicsEffects of a humanized CD47 antibody and SIRPα on triple negative breast carcinoma stem cells
Effects of a humanized CD47 antibody and SIRPα on triple negative breast carcinoma stem cells
PRJNA1036171 | ENA
TranscriptomicsEffects of a humanized CD47 antibody and SIRPα on triple negative breast carcinoma stem cells
Signal regulatory protein alpha (SIRPα, designated CD172a), also called SHPS-1 (SHP substrate 1) binds to CD47, a receptor for Thromobospondin-1 (TSP1). To block CD47-SIRP interaction, several CD47 blocking agents are in clinical trials. The purpose of this project is to explore the effects of SIRPF...
ORGANISM(S): Homo sapiens 
2024-02-20 | GSE247052 | GEO
UnknownA function-blocking CD47 antibody modulates extracellular vesicle-mediated intercellular signaling between breast carcinoma cells and endothelial cells.
Not available
S-EPMC5842190 | biostudies-literature
UnknownCD47-SIRPα blocking-based immunotherapy: Current and prospective therapeutic strategies.
Not available
S-EPMC9339239 | biostudies-literature
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