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ProteomicsAnalysis of CD5 signalosome in primary T cells
CD5 is characterized as an inhibitory co-receptor with important regulatory role during T cell development. To study the molecular mechanism by which CD5 operates, we used quantitative mass spectrometry to analyze the components of the CD5 signaling machinery in primary T cells. In a first set of ex...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-18 | PXD017343 | Pride
Tyrosine phosphorylation Cd5 Interactomics Tcr 
TranscriptomicsComparing gene expression in CD5+CD1dhigh and CD5-CD1dhigh B cells
We have previously observed that regulatory B cells expressing the apoptosis-inducing surface molecule Fas ligand were enriched in the B cell fraction denoted by a surface phenotype of CD5+CD1dhigh. To identify potential growth factors, transcriptional regulators, or surface markers that might bette...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-46245 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human 41 B-CLL samples vs. normal CD5 positive cells to identify microRNA expression patterns
The microRNA expression patterns in 41 B-CLL samples were identified by comparison with normal CD5 positive cells
ORGANISM(S): Homo sapiens 
2004-12-31 | E-MEXP-227 | biostudies-arrayexpress
TranscriptomicsCD5 alters gene transcription in Jok-1 B cells
To assess the impact of CD5 on the transcriptome in B cells, we studied changes in mRNA levels in Jok-E1A/Jok-E1B cells compared with Jok-1 cells. Gene expression was performed in untransfected CD5-negative hairy B cell leukemia line (Jok-1), transfected with cDNA for either the membrane isoform of ...
ORGANISM(S): Homo sapiens 
2013-09-11 | E-GEOD-50714 | biostudies-arrayexpress
TranscriptomicsB-cell chronic lymphocytic leukemia side population cells
Analysis of Hoechst dye 33342-effluxing side population (SP) cells from B-CLL peripheral blood mononuclear cells. 9 biological replicates from B-CLL patients sorted into CD5+CD19+ SP and non-SP subsets. Two color comparative gene expression using Agilent microarrays.
ORGANISM(S): Homo sapiens 
2011-09-26 | E-GEOD-30171 | biostudies-arrayexpress
TranscriptomicsExpression defined classification of subtypes of diffuse large B cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) comprises molecularly distinct subgroups such as activated B-cell-like (ABC) and germinal center B-cell-like (GCB) DLBCLs. We previously reported that CD5(+) and CD5(-)CD10(+) DLBCL constitute clinically relevant subgroups. To determine whether these 2 subgroups...
ORGANISM(S): Homo sapiens 
2009-07-10 | E-GEOD-16920 | biostudies-arrayexpress
UnknownA ligand for CD5 is CD5.
Not available
S-EPMC2996635 | biostudies-literature
TranscriptomicsGene expression profiling of diffuse large B-cell lymphomas supervised by CD5 expression
CD5-positive (CD5+) diffuse large B-cell lymphoma (DLBCL) has a poor prognosis and high incidence of central nervous system (CNS) relapse, even in the rituximab era. To determine the gene expression profile of CD5+ DLBCL, total RNA from 90 patients with DLBCL, including 33 CD5+ DLBCL and 57 CD5-nega...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-66770 | biostudies-arrayexpress
GenomicsRNA-seq analysis of WT, CD5 KO, CD6 KO, CD5/CD6 double KO (I) and LAT KO naïve CD4+ T cells (II)
RNA-seq analysis of WT, CD5 KO, CD6 KO, CD5/CD6 double KO (I) and LAT KO naïve CD4+ T cells (II)
PRJNA625499 | ENA
TranscriptomicsComparing gene expression in CD5+CD1dhigh and CD5-CD1dhigh B cells
We have previously observed that regulatory B cells expressing the apoptosis-inducing surface molecule Fas ligand were enriched in the B cell fraction denoted by a surface phenotype of CD5+CD1dhigh. To identify potential growth factors, transcriptional regulators, or surface markers that might bette...
ORGANISM(S): Mus musculus 
2013-06-30 | GSE46245 | GEO
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