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TranscriptomicsTranscription profiling of mouse tumoros from cdc25a over-expressing animals - (MMTV-cdc25a;MMTV-neu and MMTV-neu
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4114 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of mouse cell lines MMTV-cdc25a;MMTV-neu murine cell line
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4767 | biostudies-arrayexpress
ProteomicsHydrogen-deuterium exchange mass spectrometry analysis of the CDK2-cyclin A-CDC25A complex
The cell division cycle 25 phosphatases CDC25A, B and C regulate cell cycle transitions by dephosphorylating residues in the conserved glycine-rich loop of cyclin-dependent protein kinases (CDKs) to activate CDK activity. Here, we present HDX-MS data to complement the cryogenic-electron microscopy (...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD050866 | Pride
Cyclin a Cdc25a Cdk2 Hdx 
ProteomicsPhosphoproteomic analysis of leukemic cells after RNA interference-mediated depletion of CDC25A
Molecular and functional networks driving coordination between cell cycle and mRNA translation remain to be explored. Here, we used mass spectrometry-based proteomics to comprehensively investigate the interactome and phosphoproteome of the cell cycle regulator CDC25A. This highlighted several actor...
ORGANISM(S): Homo sapiens (Human) 
2026-07-15 | PXD066447 | Pride
Cell cycle Mrna Cdc25a Rna binding proteins Translation Lc-ms/ms 
TranscriptomicsGene expression changes resulting from cdc25a over-expression
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumori...
ORGANISM(S): Mus musculus 
2006-11-13 | GSE4114 | GEO
GenomicsGenomic aberrations in MMTV-cdc25a;MMTV-neu murine cell line
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumori...
ORGANISM(S): Mus musculus 
2006-11-13 | GSE4767 | GEO
UnknownMultimodal control of Cdc25A by nitrosative stress.
Not available
S-EPMC2680243 | biostudies-literature
UnknownPro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain.
Not available
S-EPMC2878547 | biostudies-literature
UnknownCDC25A phosphatase controls meiosis I progression in mouse oocytes.
Not available
S-EPMC2430978 | biostudies-literature
UnknownCiclopirox inhibits cancer cell proliferation by suppression of Cdc25A.
Not available
S-EPMC5489648 | biostudies-literature
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