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ProteomicsCDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma
Inhibition of cyclin-dependent kinases (CDK) 4 and 6 has become part of the current standard-of-care treatment in advanced estrogen receptor-positive advanced breast cancer. However, many tumor types are resistant to current CDK inhibitors and the therapeutic value of other CDK family members remain...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-15 | PXD039769 | Pride
Cdk18 Cdk16 
UnknownHuman CDK18 promotes replication stress signaling and genome stability.
Not available
S-EPMC5062979 | biostudies-literature
GenomicsCDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [liver tumor]
CDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [liver tumor]
PRJNA1282028 | ENA
UnknownThe relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response.
Not available
S-EPMC6047673 | biostudies-literature
GenomicsCDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [Huh7]
CDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [Huh7]
PRJNA943193 | ENA
UnknownMyc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.
Not available
S-EPMC6606647 | biostudies-literature
TranscriptomicsCDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [Huh7]
Inhibition of cyclin-dependent kinases (CDK) 4 and 6 has become part of the current standard-of-care treatment in advanced estrogen receptor-positive breast cancer. However, many tumor types are resistant to current CDK inhibitors and the therapeutic value of other CDK family members remains to be v...
ORGANISM(S): Homo sapiens 
2026-03-10 | GSE227083 | GEO
TranscriptomicsCDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [liver tumor]
Inhibition of cyclin-dependent kinases (CDK) 4 and 6 has become part of the current standard-of-care treatment in advanced estrogen receptor-positive breast cancer. However, many tumor types are resistant to current CDK inhibitors and the therapeutic value of other CDK family members remains to be v...
ORGANISM(S): Mus musculus 
2026-03-10 | GSE300751 | GEO
UnknownGenome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci.
Not available
S-EPMC10155195 | biostudies-literature
GenomicsCDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma
CDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma
PRJNA1282026 | ENA
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