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UnknownAlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor.
Not available
S-EPMC9906638 | biostudies-literature
UnknownCCRK/CDK20 regulates ciliary retrograde protein trafficking via interacting with BROMI/TBC1D32.
Not available
S-EPMC8500422 | biostudies-literature
UnknownBROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1.
Not available
S-EPMC9582636 | biostudies-literature
UnknownActivation of the ciliary kinase CDKL5 is mediated by the cyclin-dependent kinase CDK20/LF2 to control flagellar length.
Not available
S-EPMC12711092 | biostudies-literature
ProteomicsLF2 phosphorylation of the CDKL5 activation loop controls CDKL5’s activity
Cdkl5 Deficiency Disorder (CDD) is caused by variants in the protein kinase CDKL5, leading to symptoms such as seizures, developmental delay, and severe intellectual disability. The Chlamydomonas homologue of human CDKL5 is the flagellar protein LF5, whose absence results in a long flagella phenotyp...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-11-15 | PXD068782 | Pride
Cilia Cdkl5 Phospho-proteome Flagella Cdd Chlamydomonas Cdk20 Lf5 Activation loop Lf2 Phosphorylation Kinase Proteome Cdkl5 deficiency disorder 
ProteomicsLF2 phosphorylation of the CDKL5 activation loop controls CDKL5’s activity
Cdkl5 Deficiency Disorder (CDD) is caused by variants in the protein kinase CDKL5, leading to symptoms such as seizures, developmental delay, and severe intellectual disability. The Chlamydomonas homologue of human CDKL5 is the flagellar protein LF5, whose absence results in a long flagella phenotyp...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-11-15 | PXD066796 | Pride
Cilia Cdkl5 Phospho-proteome Flagella Cdd Chlamydomonas Cdk20 Lf5 Activation loop Lf2 Phosphorylation Kinase Proteome Cdkl5 deficiency disorder 
UnknownMutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment.
Not available
S-EPMC5958119 | biostudies-literature
ProteomicsLF2 phosphorylation of the CDKL5 activation loop controls CDKL5’s activity
Cdkl5 Deficiency Disorder (CDD) is caused by variants in the protein kinase CDKL5, leading to symptoms such as seizures, developmental delay, and severe intellectual disability. The Chlamydomonas homologue of human CDKL5 is the flagellar protein LF5, whose absence results in a long flagella phenotyp...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-11-18 | PXD066877 | Pride
Chlamydomonas Cilia Cdkl5 deficiency disorder Ciliopathy Intraflagellar transport Kinase Flagella 
UnknownChemistry42: An AI-Driven Platform for Molecular Design and Optimization.
Not available
S-EPMC9930109 | biostudies-literature
TranscriptomicsRestoring Taxane Efficacy in Castration Resistant Prostate Cancer Through Targeting Menin
Prostate cancer (PC) typically depends on hormones for growth, with androgen deprivation therapy (ADT) serving as the primary treatment. However, many patients progress to a castration-resistant (CR) stage, where their tumor becomes unresponsive to ADT. Despite the common use of conventional chemoth...
ORGANISM(S): Homo sapiens 
2025-07-31 | GSE302154 | GEO
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