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ProteomicsCoiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation
Coiled-coil domain-containing 68 (CCDC68) plays different roles in cancer and is predicted as a tumor suppressor in human colorectal cancer (CRC). However, the specific role of CCDC68 in CRC and the underlying mechanisms remain unknown. Here, we showed that CCDC68 expression was lower in CRC than in...
ORGANISM(S): Homo sapiens (Human) 
2021-04-14 | PXD024343 | Pride
Ccdc68 Itch Cdk4 degradation Cell proliferation Colorectal cancer 
ProteomicsRb and the APC/C coactivator FZR1 determine CDK4/6-Cyclin D requirement in C. elegans and human cancer cells
Cyclin dependent kinase 4 and 6 (CDK4/6) in complex with D-type cyclins promote cell cycle entry, at least in part through phosphorylation of the retinoblastoma tumor suppressor protein (Rb). The CDK4/6-cyclin D-Rb pathway is commonly deregulated in human cancer, often through CDK4/6 or D-type cycli...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2016-07-05 | PXD001501 | Pride
Lin-35 fzr1 
UnknownMYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation.
Not available
S-EPMC10904810 | biostudies-literature
UnknownOptochemical control of G1 cell cycle by regulating CDK4/6 degradation.
Not available
S-EPMC12398220 | biostudies-literature
ProteomicsAn integrative multi-omics approach uncovers the regulatory role of Cdk7 and Cdk4 in autophagy induced by silica nanoparticles
The abnormal induction of macroautophagy/autophagy, a highly conserved lysosome-based degradation pathway, has been postulated as a major toxicity of nanomaterials, whereas little is known on the exact molecular mechanisms. Here, we treated mammalian cells with 16 nm silica nanoparticles (SiNPs), co...
ORGANISM(S): Rattus Norvegicus 
2019-12-01 | PXD012196 |
UnknownCyclin D1-cdk4 induce runx2 ubiquitination and degradation.
Not available
S-EPMC2649830 | biostudies-literature
UnknownAutophagic degradation of CDK4 is responsible for G0/G1 cell cycle arrest in NVP-BEZ235-treated neuroblastoma.
Not available
S-EPMC11296530 | biostudies-literature
UnknownCoiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation.
Not available
S-EPMC8100586 | biostudies-literature
UnknownTargeted degradation of CDK4/6 by LA-CB1 inhibits EMT and suppresses tumor growth in orthotopic breast cancer.
Not available
S-EPMC11880390 | biostudies-literature
GenomicsA non-canonical function of the tyrosine degradation enzyme FAH drives CDK4/6 inhibitor resistance in breast cancer II
A non-canonical function of the tyrosine degradation enzyme FAH drives CDK4/6 inhibitor resistance in breast cancer II
PRJNA1464537 | ENA
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