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TranscriptomicsGene expression profiling of CEBPA double-, single-mutant and CEBPA wild type AML
A previously predictive CEBPA double mutant (CEBPAdm) signature was hampered by the recently reported CEBPA silenced AML cases that carry a similar gene expression profile (GEP). Two independent AML cohorts were used to train and evaluate the predictive value of the CEBPAdm signature in terms of sen...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-22845 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation in CEBPA mutant and CEBPA silenced AML
Acute Myeloid Leukemia (AML) is a heterogeneous disease from the molecular and biological standpoints, and even patients with a specific gene expression profile may present clinical and molecular heterogeneity. We studied the epigenetic profiles of a cohort of patients that shared a common gene expr...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-14417 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of mono- and biallelic CEBPA mutations in cytogenetically normal AML
Purpose: CEBPA mutations are found as either biallelic (biCEBPA) or monoallelic (moCEBPA). We set out to explore whether the kind of CEBPA mutation is of prognostic relevance in cytogenetically normal AML (CN-AML). Patients and Methods: 467 homogeneously treated CN-AML patients were subdivided into ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-15210 | biostudies-arrayexpress
ProteomicsIdentification of CEBPA and RUNX1 interactors in 3q-rearranged AML
Chromatin immunoprecipitation with specific isolation of chromatin associated proteins (ChIP-SICAP) was used to identify chromatin-bound interactors of CEBPA and RUNX1 in the 3q-rearranged human myeloid leukemia cell line MUTZ-3.
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD020045 | Pride
Runx1 Acute myeloid leukemia Chip-sicap Cebpa Human 
ProteomicsThe p30 isoform of CEBPA uncovers a silent enhancer to drive the expression of the tumor promoting factor CD73 in CEBPA mutant AML
The key myeloid transcription factor (TF) CEBPA is frequently mutated in acute myeloid leukemia (AML), but the molecular ramifications of this leukemic driver mutation remain elusive. To investigate CEBPA mutant AML, we compared gene expression changes in human CEBPA mutant AML and in the correspond...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-08 | PXD011359 | Pride
Cebpa Global proteomics Acute myeloid leukemia 
TranscriptomicsTranscription profiling of human CEBPA mutant and CEBPA silenced AML and in T-ALL
Acute Myeloid Leukemia (AML) is a heterogeneous disease from the molecular and biological standpoints, and even patients with a specific gene expression profile may present clinical and molecular heterogeneity. We studied the epigenetic profiles of a cohort of patients that shared a common gene expr...
ORGANISM(S): Homo sapiens 
2009-01-24 | E-GEOD-14479 | biostudies-arrayexpress
GenomicsChIP-seq data of HNF4A, CEBPA, FOXA1, H3K27ac,
We profiled the genome-wide occupancy of three tissue-specific transcription factors, HNF4A, CEBPA and FOXA1, as well as the genome-wide occurrence of the histone mark, H3K4me3 in the livers of two inbred parental mouse strains (C57BL/6J and CAST/EiJ) and their F1 crosses. We also included H3K27ac d...
ORGANISM(S): Mus 
2016-06-30 | E-MTAB-4089 | biostudies-arrayexpress
ProteomicsIdentification of CEBPA and RUNX1 interactors in 3q-rearranged AML (MOLM-1)
Chromatin immunoprecipitation with specific isolation of chromatin associated proteins (ChIP-SICAP) was used to identify chromatin-bound interactors of CEBPA and RUNX1 in the 3q-rearranged human myeloid leukemia cell line MOLM-1.
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD020050 | Pride
Runx1 Acute myeloid leukemia Chip-sicap Cebpa Human 
ProteomicsIdentification of CEBPA and RUNX1 interactors in 3q-rearranged AML (HNT-34)
Chromatin immunoprecipitation with specific isolation of chromatin associated proteins (ChIP-SICAP) was used to identify chromatin-bound interactors of CEBPA and RUNX1 in the 3q-rearranged human myeloid leukemia cell line HNT-34.
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD020054 | Pride
Runx1 Acute myeloid leukemia Chip-sicap Cebpa Human 
TranscriptomicsMultilineage dysplasia does not influence prognosis in patients with CEBPA mutated AML supporting the WHO proposal to classify these patients as a unique entity
By WHO 2008, CEBPA-mutated AML became a provisional subentity, but it remains to be clarified how CEBPAmut AML with multilineage dysplasia (MLD; ?50% dysplastic cells in 2-3 lineages) but no other MDS-related feature should be classified. We investigated 108 CEBPAmut AML (15.7-87.6 years) for the im...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-33223 | biostudies-arrayexpress
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