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TranscriptomicsscRNAseq of hiPSC, iMeLC, hPGCLC aggregates and hEGCLC of CTL08A genotype
In this work, hEGCLC have been obtained for the first time from hPGCLC in defined and feeder-free conditions. To study transcriptional changes during the transition from a pluripotent stem cell state to a germ cell identity and back again, we profiled hiPSC, iMeLC, day6 hPGCLC aggregates and hEGCLC ...
ORGANISM(S): Homo sapiens 
2026-02-10 | E-MTAB-15244 | biostudies-arrayexpress
ProteomicsAging-triggered iron-rich insoluble protein aggregates in the spleen originate chiefly from red pulp macrophages.
Both iron homeostasis and erythropoiesis are known to be affected by aging. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by red pulp macrophages (RPMs) in the spleen. Given that RPMs continuously process iron, their cell...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-02 | PXD038660 | Pride
Iron-rich protein aggregates Iron-dextran injection Mouse Red pulp macrophages Spleen 
TranscriptomicsTranscriptome profile in the human synovial MSC-aggregates
One of strategies to regenerate cartilage defect is transplantation of mesenchymal stem cells (MSCs). Improvements of therapeutic potential of MSCs are needed to achieve successful cartilage regeneration by transplantation of a limited number of cells. Aggregated culture is a popular method in ES an...
ORGANISM(S): Homo sapiens 
2012-05-12 | E-GEOD-31980 | biostudies-arrayexpress
MetabolomicsCell-intrinsic metabolic phenotypes identified in glioblastoma patients using mass spectrometry imaging of 13C-labeled glucose metabolism

Transcriptomic studies attempted to classify glioblastoma (GB) into subtypes that predict survival and that have different therapeutic vulnerabilities1-3. Here we identified three metabolic subtypes: glycolytic, oxidative and a mixed glycolytic/oxidative by mass spectrometry imaging of rapidly ex...

2025-05-08 | MTBLS12176 | MetaboLights
TranscriptomicsGlobal expression of mouse hepatocytes cultured as monolayers or as three-dimensional aggregates
Three-dimensional (3D) culture of hepatocytes leads to improved and prolonged synthetic and metabolic functions, but the underlying molecular mechanisms were unknown. In order to investigate the molecular mechanisms underlying 3D cell-cell interactions in maintaining hepatocyte differentiated funct...
ORGANISM(S): Mus musculus 
2013-12-23 | E-GEOD-53054 | biostudies-arrayexpress
TranscriptomicsNovel Immunotherapy-Induced Tertiary Lymphoid Aggregates Accumulate as Intratumoral Nodal Structures of Immune Regulation in Pancreatic Cancer
Immunotherapy provides an alternative approach for cancer treatment. However, in-depth analyses of the effects of immunotherapy on the tumor microenvironment (TME) have not been conducted in non-melanoma tumors. Here we describe changes in the pancreatic ductal adenocarcinoma (PDAC) TME following i...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-52171 | biostudies-arrayexpress
GenomicsGeneration of mandibular prominence ectomesenchyme (mdEM) from human induced pluripotent stem cell (iPSC)-derived neural crest cell (NCC) aggregates
Generation of mandibular prominence ectomesenchyme (mdEM) from human induced pluripotent stem cell (iPSC)-derived neural crest cell (NCC) aggregates
PRJNA1089208 | ENA
GenomicsALS associated TDP-43 aggregates drive innate and adaptive immune cell activation
ALS associated TDP-43 aggregates drive innate and adaptive immune cell activation
PRJNA1245461 | ENA
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set5: TMT dataset of aggregates in mitochondria
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD048691 | Pride
Mitochondria aggregates 
GenomicsInduction of osteogenic lineage cells from human induced pluripotent stem cell (iPSC)-derived neural crest cell (NCC) aggregates through mandibular prominence ectomesenchyme (mdEM)
Induction of osteogenic lineage cells from human induced pluripotent stem cell (iPSC)-derived neural crest cell (NCC) aggregates through mandibular prominence ectomesenchyme (mdEM)
PRJNA1088515 | ENA
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