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ProteomicsA pore-forming toxin initiates ABI1 complex switching to promote bacterial cell-to-cell spread
Listeria monocytogenes (Lm), a prototypical intracellular bacterial pathogen, expresses ActA to initiate ARP2/3-mediated actin-based motility in the cytosol of host cells. Motile bacteria generate Lm-containing protrusions at the cell surface, facilitating direct cell-to-cell spread and disseminatio...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD074581 | Pride
Cell-to-cell spread Listeria Infectious diseases Ip-ms 
GenomicsHIV cell-to-cell spread slows evolution of drug resistance
HIV cell-to-cell spread slows evolution of drug resistance
PRJNA661547 | ENA
ProteomicsHIV-1 activates T cell signaling independently of antigen to drive viral spread
HIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways we developed an approach to analyze the phosphoproteome in infected and uninfected mixed population T cells using differ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD005658 | Pride
T cell Hiv Phosphorylation Virological synapse 
MetabolomicsSingle-cell and bulk level metabolomic study of the glycolysis inhibition by 2-deoxy-D-glucose in Saccharomyces cerevisiae
Single-cell level measurements are necessary to characterize the intrinsic biological variability in a population of cells. In a study of the metabolic response of a clonal Saccharomyces cerevisiae population challenged by the glycolytic inhibitor 2-deoxy-D-glucose (2-DG), this variability is shown ...
2013-05-22 | MTBLS29 | MetaboLights
ProteomicsROS are evolutionary conserved cell-to-cell stress signals
Cell-to-cell communication is fundamental to multicellular organisms and unicellular organisms living in a microbiome. It is thought to have evolved as a stress- or quorum-sensing mechanism in unicellular organisms. A unique cell-to-cell communication mechanism that uses reactive oxygen species (ROS...
ORGANISM(S): Chlamydomonas reinhardtii 
2024-05-24 | PXD042594 | Pride
Dia-pasef Reactive oxygen species (ros) Cell-to-cell communication 
OtherHIV cell-to-cell spread slows evolution of drug resistance
Here we investigated whether a combination of cell-free infection and cell-to-cell spread confers a selective advantage in the evolution of resistance to an inhibitor relative to cell-to-cell spread alone due to the stronger selection pressure against drug sensitive virus. We propagated HIV infectio...
ORGANISM(S): Homo sapiens 
2020-09-05 | GSE157511 | GEO
TranscriptomicsHost cell responses to persistent mycoplasmas--different stages in infection of HeLa cells with Mycoplasma hominis
M. hominis adherence, colonisation and invasion of HeLa cells were characterised in a time-course study using microarray-based analysis of the HeLa cell transcriptome: 0 h to monitor the baseline of transcription, 4 h to examine host reactions to mycoplasma attachment, 48 h to capture in addition th...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-54698 | biostudies-arrayexpress
UnknownListeria monocytogenes exploits efferocytosis to promote cell-to-cell spread.
Not available
S-EPMC4151619 | biostudies-literature
TranscriptomicsInduction of epididymis specific G-protein coupled receptor-64 (GPR64) in Ewing Tumors supports invasiveness and metastatic spread
Metastatic spread in Ewing Tumors (ET) is hematogenous and malignant features have been shown to correlate with hypoxia and angiogenesis. We identified several Ewing tumor specific genes (Staege MS et al. Cancer Res. 2004;64:8213-21). Microarray analysis confirmed an endothelial signature of this tu...
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-23058 | biostudies-arrayexpress
UnknownHIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.
Not available
S-EPMC6714792 | biostudies-literature
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