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MetabolomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
ProteomicsExtracellular Matrix Analysis of Human Varicose Veins
To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting the extracellular matrix.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-17 | MSV000080062 | MassIVE
ProteomicsProteomic characterization of extracellular matrix (ECM) produced by human fibroblast activation protein (FAP)-positive pericyte-like cells and glioma cells
Fibroblast activation protein (FAP) is upregulated in most cancers and represents an emerging theranostic target in oncology. In glioblastoma (GBM), FAP is predominantly expressed in mesenchymal pericyte-like cells, which contribute to GBM progression by promoting angiogenesis and glioma cell prolif...
ORGANISM(S): Homo Sapiens 
PXD045057 | panorama
ProteomicsExtracellular Matrix proteomics
Proteomics of extracellular matrix from fibroblast cell cultures (WI-38). The results of these experiments were used to supprt an electron microscopy study of the extracellular matrix.
ORGANISM(S): Homo sapiens (Human) 
2019-03-13 | PXD007700 | Pride
Extracellular matrix Ecm 
ProteomicsWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
The endosomal FYVE- and WD40-domain-containing protein WDFY2 has been assigned a function as tumor suppressor, but its functional mechanism has remained elusive. Here we have used confocal, widefield and super-resolution fluorescence microscopy to show that WDFY2 localizes to the base of retromer-co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-23 | MSV000084122 | MassIVE
ProteomicsThe matrisome: in silico definition and in vivo characterization of tumor extracellular matrix
Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO. Mol Cell Proteomics 2012, 11: M111.014647. doi:10.1074/mcp.M111.014647. PMCID:PMC3322572. Tranche_hash:onoKvMCC9umP0dW2GlZSGN/DVfz6tqoyRvsA16h351RjGJZiqjk0wWGYQB9+zPpRj+ASAgKsd779N0Td4250FCPJ6jUAAAAAAABFoQ==
2013-11-20 | MSV000078494 | MassIVE
ProteomicsIncreased levels of extracellular matrix proteins in extracellular vesicles from brains of aged mice.
Extracellular vesicles (EVs) have several functions in the brain, serving as a mode of intercellular communication and as a pathway for disposal of cellular debris. While these functions serve to maintain healthy brain function, they may also contribute to diseases affecting the brain. EVs also chan...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052797 | Pride
Aging Extracellular vesicles Extracellular matrix Lcms Mouse model Proteomics 
ProteomicsProtein composition of the extracellular matrix in idiopathic germ cell aplasia
The somatic microenvironment supports spermatogonial stem cell differentiation into sperm. Extracellular matrix (ECM) plays multiple roles in the stem cell niche, including self-renewal, proliferation, differentiation and survival of spermatogonial cells. The pathophysiology of male infertility mig...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011817 | Pride
Extracellular matrix  male infertility  label-free quantitative proteomics 
ProteomicsMouse kidney glomerular extracellular matrix LC-MSMS
Across the spectrum of human disease there are significant changes in the composition and organisation of extracellular matrix (ECM). Furthermore, disease severity can vary according to race and sex, yet mechanisms for these variations are unclear. Using the kidney glomerulus as a model system, we t...
ORGANISM(S): Mus musculus (Mouse) 
2016-07-09 | PXD000811 | Pride
Lc-msms Mouse Kidney Glomerular Extracellular matrix 
UnknownA Single-Step Protein Extraction for Lung Extracellular Matrix Proteomics Enabled by the Photocleavable Surfactant Azo and timsTOF Pro.
Not available
S-EPMC12535824 | biostudies-literature
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