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MetabolomicsNanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
MetabolomicsIn Vivo CRISPR Screens Identify SLC1A5 as a Metabolic Barrier for Cancer Immunotherapy
Tumor metabolic reprogramming profoundly shapes antitumor immunity, but the mechanisms linking glutamine metabolism to immune evasion in hepatocellular carcinoma (HCC) remain incompletely understood. Here, we identify the glutamine transporter SLC1A5 as a tumor-intrinsic regulator of HCC progression...
2026-08-20 | MTBLS15401 | MetaboLights
TranscriptomicsIL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
IL-2 and IL-21 are closely related cytokines that might have arisen by gene duplication. Both cytokines promote the function of effector CD8+ T cells, but their distinct effects on antigen-driven differentiation of naïve CD8+ T cells into effector CD8+ T cells are not clearly understood. We found t...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10403 | biostudies-arrayexpress
TranscriptomicsPredictive Gene Signatures as Strong Prognostic Indicators of the Effectiveness of BCG Immunotherapy
Full title: Predictive Gene Signatures as Strong Prognostic Indicators of the Effectiveness of Bacillus Calmetteâ??Guérin (BCG) Immunotherapy in Primary pT1 Bladder Cancers Intravesical BCG immunotherapy is effective in prevention of recurrence and progression in many cases of non-muscle invasive b...
ORGANISM(S): Homo sapiens 
2010-04-07 | E-GEOD-19423 | biostudies-arrayexpress
ProteomicsDiscovery and development of CLL-1 as a cellular immunotherapy target in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is an aggressive hematologic malignancy with myeloproliferative characteristics that affects young children and is associated with significant morbidity and mortality. Leukemia stem cells (LSCs) have been shown to drive relapse and progression in JMML and incl...
ORGANISM(S): Homo sapiens (Human) 
2025-02-03 | PXD052910 | Pride
Jmml Surfaceomics Car-t cell Immunotherapy 
UnknownHigh-affinity CD16 integration into a CRISPR/Cas9-edited CD38 locus augments CD38-directed antitumor activity of primary human natural killer cells.
Not available
S-EPMC8830298 | biostudies-literature
TranscriptomicsDNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy
Cancers evade the immune system in order to grow or metastasise through the process of cancer immunoediting. While checkpoint inhibitor therapy has been effective for reactivating tumour immunity in some cancers, many solid cancers, including breast cancer, remain largely non-responsive. Understandi...
ORGANISM(S): Mus musculus 
2021-09-01 | E-MTAB-10027 | biostudies-arrayexpress
TranscriptomicsNovel Immunotherapy-Induced Tertiary Lymphoid Aggregates Accumulate as Intratumoral Nodal Structures of Immune Regulation in Pancreatic Cancer
Immunotherapy provides an alternative approach for cancer treatment. However, in-depth analyses of the effects of immunotherapy on the tumor microenvironment (TME) have not been conducted in non-melanoma tumors. Here we describe changes in the pancreatic ductal adenocarcinoma (PDAC) TME following i...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-52171 | biostudies-arrayexpress
UnknownDefining tumor resistance to PD-1 pathway blockade: recommendations from the first meeting of the SITC Immunotherapy Resistance Taskforce.
Not available
S-EPMC7174063 | biostudies-literature
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