Cenp-c - OmicsDI

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-|DG -/8:0/26:1,8:0/-/26:1|- (1)

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Lab affiliation

Dr Fede Pelisch Principal Investigator Molecular Cell and Developmental Biology School of Life Sciences University of Dundee Dundee UK (1)
Head of the Curie Institute Mass Spectrometry Platform (1)
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Uppsalalaan 8, 3584CT, Utrecht, the Netherlands. (1)
Institut Curie, CNRS, UMR 144, 26 rue dÃ¢â‚¬â„¢Ulm, 75005 Paris, France (1)
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Institute of Parasitology, Biology Center, Czech Academy of Sciences, Branišovská 31, 370 05 České Budějovice, CZECH REPUBLIC (1)
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Wellcome Centre for Cell Biology, University of Edinburgh Institute of Biotechnology, Technische Universität Berlin (1)

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The N-terminal Tail of CENP-A Confers Epigenetic Stability to Centromeres via the CENP-T Branch of the CCAN in Fission Yeast

We employ the well-studied fission yeast centromere to investigate the function of the CENP-A (Cnp1) N-tail. We show that alteration of the N-tail did not affect Cnp1 loading at centromeres, outer kinetochore formation, or spindle checkpoint signaling, but nevertheless elevated chromosome loss. N-Ta...

ORGANISM(S): Schizosaccharomyces pombe

2015-04-16 | E-GEOD-63350 | biostudies-arrayexpress

CENP-C-targeted PLK-1 regulates kinetochore function in C. elegans embryos

This project focused on the identification of phosphorylation sites on the C. elegans inner kinetochore protein CENP-C and the outer kinetochore complex MIS12. Phosphorylation was carried out in vitro using recombinant proteins. CENP-C was phosphorylated with Cdk1, PLK-1 or both; MIS12 complex compo...

ORGANISM(S): Caenorhabditis elegans

2024-11-28 | PXD058379 | Pride

To detect CENP-A enrichment on Chromosome 1,5 &7 in C. albicans centromere deleted clones

ChIP Seq revealed presence of unique CEN-proximal neocentromere peaks in CEN deleted clones. Using 10 million reads generated from ChIP-seq for each sample, chromosome wide maps for CENP-A enrichment were generated . Examination of CENP-A enrichment in Input/IP samples of various CEN deleted C. a...

ORGANISM(S): Candida albicans

2012-12-21 | E-GEOD-42907 | biostudies-arrayexpress

CENP-T and CENP-C bridge adjacent CENP-A nucleosomes on young alpha-satellite dimers

We find that CENP-T acts as a bridge between two well-positioned CENP-A nucleosomes that are present on young alpha-satellite dimers that dominate functional human centromeres. CENP-T is centered over the CENP-B box, where it interacts with the CENP-B/CENP-C complex. Upon cross-linking, the entire C...

ORGANISM(S): Homo sapiens

2016-05-24 | GSE69839 | GEO

CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.

Not available

S-EPMC6776904 | biostudies-literature

Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.

Not available

S-EPMC4610723 | biostudies-literature

Cryo-EM structure of the CENP-A nucleosome in complex with phosphorylated CENP-C.

Not available

S-EPMC7917552 | biostudies-literature

CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization.