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ProteomicsCENP-C-targeted PLK-1 regulates kinetochore function in C. elegans embryos
This project focused on the identification of phosphorylation sites on the C. elegans inner kinetochore protein CENP-C and the outer kinetochore complex MIS12. Phosphorylation was carried out in vitro using recombinant proteins. CENP-C was phosphorylated with Cdk1, PLK-1 or both; MIS12 complex compo...
ORGANISM(S): Caenorhabditis elegans 
2024-11-28 | PXD058379 | Pride
Plk-1 Inner kinetochore Cenp-c Mis12 complex. 
ProteomicsIdentification of tissue-specific SPD-5 and PLK-1 proximity interactors by direct and indirect TurboID
In this set of proof of principle experiments we compare the proximity interactomes obtained for two C. elegans centrosomal proteins, SPD-5 and PLK-1, by direct TurboID and indirect, GFP nanobody-targeted, TurboID in a range of different tissues, embryos, germ cell precursors and ciliated neurons.
ORGANISM(S): Caenorhabditis elegans 
2022-04-01 | PXD031970 | Pride
C. elegans  centrosome  interaction mapping  turboid 
GenomicsThe effect of Dual Aurora A and PLK-1 kinases inhibitor to gene expressions
The effect of Dual Aurora A and PLK-1 kinases inhibitor to gene expressions
PRJNA415131 | ENA
GenomicsOnly infant MLL rearranged leukemia is susceptible to an inhibition of PLK-1 by volasertib
Only infant MLL rearranged leukemia is susceptible to an inhibition of PLK-1 by volasertib
PRJNA1158260 | ENA
UnknownPLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis.
Not available
S-EPMC4628734 | biostudies-literature
TranscriptomicsOnly infant MLL rearranged leukemia is susceptible to an inhibition of PLK-1 by volasertib
MLL rearranged (MLLr) leukemia is in general characterized by a poor prognosis. Depending on the cell of origin, it can differ in the aggressiveness and the therapy response. For instance, in adults, volasertib blocking Polo-like-Kinase 1 (PLK-1), was well-tolerated, but only with limited success. O...
ORGANISM(S): Homo sapiens 
2024-12-19 | GSE276639 | GEO
UnknownDynamin regulates PLK-1 localization and spindle pole assembly during mitosis.
Not available
S-EPMC12330643 | biostudies-literature
UnknownCENP-C-targeted PLK-1 regulates kinetochore function in C. elegans embryos.
Not available
S-EPMC11634037 | biostudies-literature
TranscriptomicsThe effect of Dual Aurora A and PLK-1 kinases inhibitor to gene expressions
We designed and developed new chemical agents (AAPK) simultaneously targeting on the suppression of Aurora-A/PLK-1 activities. We used microarrays to investigate the whole gene expressions after AAPK administration in comparison to DMSO control.
ORGANISM(S): Homo sapiens 
2017-10-21 | GSE105411 | GEO
UnknownPLK-1 regulates MEX-1 polarization in the <i>C. elegans</i> zygote.
Not available
S-EPMC11291152 | biostudies-literature
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