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ProteomicsThe effect of an MLK3-targeting PROTAC on protein levels in model breast cancer cell lines.
The objective of the study was to explore how a new compound (CEP1347-VHL-02 PROTAC) which facilitates the breakdown of mitogen-activated protein kinase kinase kinase 11 (MLK3), affects the protein quantities in the total cell extracts from specific breast cancer cell models. The cell lines used in ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD050260 | Pride
Mlk3 Cep1347-vhl-02 protac Hcc1806 Mcf-7 Mda-mb-468 
UnknownSelective Degradation of MLK3 by a Novel CEP1347-VHL-02 PROTAC Compound Limits the Oncogenic Potential of TNBC.
Not available
S-EPMC11403673 | biostudies-literature
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