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TranscriptomicsDissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation
MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of highly invasive ...
ORGANISM(S): Homo sapiens 
2014-03-21 | E-GEOD-54611 | biostudies-arrayexpress
ProteomicsThe effect of an MLK3-targeting PROTAC on protein levels in model breast cancer cell lines.
The objective of the study was to explore how a new compound (CEP1347-VHL-02 PROTAC) which facilitates the breakdown of mitogen-activated protein kinase kinase kinase 11 (MLK3), affects the protein quantities in the total cell extracts from specific breast cancer cell models. The cell lines used in ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD050260 | Pride
Mlk3 Cep1347-vhl-02 protac Hcc1806 Mcf-7 Mda-mb-468 
GenomicsAnalysis of MLK3-dependent gene expression in carcinogen-induced murine hepatocellular carcinoma
Analysis of MLK3-dependent gene expression in carcinogen-induced murine hepatocellular carcinoma
PRJNA974857 | ENA
GenomicsRNA sequencing analysis of TNBC PDX treated with MLK3 and pan MLK's inhibitor
RNA sequencing analysis of TNBC PDX treated with MLK3 and pan MLK's inhibitor
PRJNA780884 | ENA
TranscriptomicsAnalysis of MLK3-dependent gene expression in carcinogen-induced murine hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common gastrointestinal (GI) malignancies and a major cause of death worldwide, with limited therapeutic options. Although Mixed Lineage Kinase 3 (MLK3), a MAPKKK, has emerged as a key regulator of acute liver injury, inflammation, and non-alcoholic ...
ORGANISM(S): Mus musculus 
2024-04-29 | GSE233074 | GEO
GenomicsRNA Sequencing Gene Expression Profiles in Wild-Type and MLK2 and MLK3 double knockout (MLK2-/-MLK3-/-) Mouse Lung Endothelial Cells Under Normoxic and Hypoxic Conditions
RNA Sequencing Gene Expression Profiles in Wild-Type and MLK2 and MLK3 double knockout (MLK2-/-MLK3-/-) Mouse Lung Endothelial Cells Under Normoxic and Hypoxic Conditions
PRJNA1254720 | ENA
TranscriptomicsRNA sequencing analysis of TNBC PDX treated with MLK3 and pan MLK's inhibitor
Mixed Lineage Kinase 3 (MLK3) is a viable emerging target for neoplastic diseases; however, it is uncertain whether its activators or inhibitors can act as anti-neoplastic agents. Previously, we reported that the kinase activity of MLK3 was significantly higher in triple-negative breast cancer (TNBC...
ORGANISM(S): Homo sapiens 
2023-03-01 | GSE188947 | GEO
TranscriptomicsRNA Sequencing Gene Expression Profiles in Wild-Type and MLK2 and MLK3 double knockout (MLK2-/-MLK3-/-) Mouse Lung Endothelial Cells Under Normoxic and Hypoxic Conditions
MLK2 and MLK3 are key regulators of angiogenesis, particularly under hypoxic conditions. To investigate the underlying mechanisms, we performed unbiased RNA sequencing on primary lung endothelial cells isolated from wild-type and MLK2 and MLK3 double knockout (MLK2-/-MLK3-/-) mice exposed to normoxi...
ORGANISM(S): Mus musculus 
2025-04-23 | GSE295461 | GEO
UnknownMechanisms underlying melanoma invasion as a consequence of MLK3 loss.
Not available
S-EPMC9086996 | biostudies-literature
TranscriptomicsDissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation
MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of highly invasive ...
ORGANISM(S): Homo sapiens 
2014-03-21 | GSE54611 | GEO
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