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MetabolomicsCeramide Promotes Lytic Reactivation of Epstein-Barr Virus in Gastric Carcinoma
Epstein-Barr virus (EBV) has a lifelong latency period after initial infection. Rarely, however, when the EBV immediate early gene BZLF1 is expressed by a specific stimulus, the virus switches to the lytic cycle to produce progeny viruses. We found that EBV infection reduced levels of various cerami...
2023-12-20 | MTBLS7649 | MetaboLights
ProteomicsLiver proteome upon in vivo N-acetylgalactosamine-conjugated antisense oligonucleotide silencing of ceramide synthase 2
Mouse liver proteome was investigated upon in vivo mouse treatment with a N-acetylgalactosamine-conjugated antisense oligonucleotide engineered to silence ceramide synthase 2 specifically in hepatocytes in vivo. The data is a part of a study on the involvement of ceramide enzymatic machinery in card...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD025957 | Pride
Silencing Liver Mouse Proteome Ceramide synthase 2 
ProteomicsFatty acid transport protein 2 interacts with ceramide synthase 2 to regulate ceramide synthesis
Dihydroceramide is generated via the action of (dihydro)ceramide synthases (CerSs), which use two substrates, namely sphinganine and fatty acyl CoAs. Sphinganine is generated via the sequential activity of two integral membrane proteins located in the endoplasmic reticulum. Less is known about the s...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD031088 | Pride
Ceramide synthase Dihydroceramide Ceramide Fatty acid transport protein Sphingolipids 
MetabolomicsClinical Application Value of Ceramide and Sphingomyelin as Biomarkers for the Diagnosis of Drug-Induced Liver Injury

Background : Drug-induced liver injury (DILI) is a serious health concern that presents challenges in early detection and accurate diagnosis, thereby complicating the treatment of this liver disease. Therefore, it is crucial to explore specific biomarkers to improve the accuracy of diagnosing DIL...

2025-07-23 | MTBLS12765 | MetaboLights
GenomicsAging stress and ceramide dependent RNA sequencing expression profiling depends on ceramide synthase 6
Aging stress and ceramide dependent RNA sequencing expression profiling depends on ceramide synthase 6
PRJNA624654 | ENA
TranscriptomicsAging stress and ceramide dependent RNA sequencing expression profiling depends on ceramide synthase 6
The bioactive sphingolipid ceramide, generated by ceramide synthase, is an adaptive stress effector induced in response to various stress stimuli such as aging. In fact, ceramide synthase (CerS) was first discovered in yeast as a longevity assurance gene (LAG1), as the reduced ceramide generation co...
ORGANISM(S): Mus musculus 
2021-01-01 | GSE148498 | GEO
ProteomicsA novel C-terminal DxRSDxE motif in ceramide synthases involved in dimer formation
Ceramide is synthesized via the ceramide synthases (CerSs), six of which have been identified in mammalian cells, with each using a unique subset of acyl-CoAs for ceramide synthesis. The CerSs are part of a larger gene family, the Tram-Lag-CLN8 (TLC) domain family. We now identify a unique, C-termin...
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD029496 | Pride
Motif Ceramide synthase Ceramide Dimer Sphingolipids 
UnknownSilencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death.
Not available
S-EPMC9077316 | biostudies-literature
UnknownEctopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency.
Not available
S-EPMC4889366 | biostudies-literature
UnknownCeramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells.
Not available
S-EPMC8237407 | biostudies-literature
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