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MetabolomicsLC-MS-Based Serum Metabolomics Reveals Distinct Metabolic Signatures in Patients with Cerebral Infarction

This study applied serum metabolomics to compare patients with cerebral infarction (n=10) and controls (n=10). A total of 3,160 metabolites were identified, with distinct class distributions between groups. Cerebral infarction patients showed elevated benzene derivatives, organic acids, and bile ...

2025-09-24 | MTBLS13031 | MetaboLights
MetabolomicsIntegrated Analysis of Gut Microbiota, Serum Metabolomics, and Proteomics Reveals Novel Associations With Clinical Symptoms in Patients With Cerebral Infarction
Cerebral infarction (CI) is a major cause of adult disability and mortality worldwide. Mounting evidence supports the critical role of the gut–brain axis in cerebrovascular disease progression. This study aimed to characterize the alterations in gut microbiota, serum metabolome, and serum proteome i...
2026-05-08 | MTBLS14356 | MetaboLights
MetabolomicsNMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort
Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this study was to investigate the metabolomic fingerprint of acute myocardial infarction using nu...
2018-10-02 | MTBLS395 | MetaboLights
MetabolomicsMetabolome of 334 cerebral thrombi (in four batches) retrieved by mechanical thrombectomy after ischemic stroke due to large vessel occlusion (Retro-MATISSE study)

The Retro-MATISSE study (Molecular Analysis of Thrombus for Ischemic Stroke prognosiS and Etiology) aimed to characterize the metabolome of 334 thrombi <...

2026-04-25 | MTBLS14374 | MetaboLights
MetabolomicsTherapeutic Effect of Buyang Huanwu Decoction on the Gut Microbiota and Hippocampal Metabolism in a Rat Model of Cerebral Ischemia

Buyang Huanwu decoction (BHD) is a well-known Chinese herbal prescription. It has been widely used in the clinical treatment of cerebral ischemia (CI) in China. However, the mechanism underlying the treatment of CI with BHD remains to be elucidated. In this study, we combined microbiomic and meta...

2022-06-02 | MTBLS4366 | MetaboLights
MetabolomicsIntegrated multi-omics reveals gut microbiota–metabolic mechanisms underlying the neuroprotective effects of Xijiao Dihuang Decoction against cerebral ischemia–reperfusion injury
This study investigated the effects of Xijiao Dihuang Decoction (XDD) on cerebral ischemia–reperfusion injury using a middle cerebral artery occlusion/reperfusion rat model. Untargeted LC–MS metabolomics was performed on fecal samples to characterize metabolic alterations associated with MCAO/R and ...
2026-09-23 | MTBLS15783 | MetaboLights
TranscriptomicsTranscription profiling of mouse forebrain with induced middle cerebral artery occlusion (MCAO) to study permanent focal cerebral ischemia
profiling gene transcription in a mouse model of permanent focal cerebral ischemia that was induced by middle cerebral artery occlusion (MCAO)
ORGANISM(S): Mus musculus 
2009-03-07 | E-TABM-655 | biostudies-arrayexpress
ProteomicsQuantitative Proteomics Revealed the Mechanism of the Buyanghuanwu Decoction used to Treat Cerebral Infarction
To explore the efficacy of BYHW in the clinical treatment of cerebral infarction
ORGANISM(S): Homo Sapiens 
2022-12-13 | PXD038796 |
TranscriptomicsIdentification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke
Because most human stroke victims are elderly, studies of experimental stroke in the aged rather than the young rat model may be optimal for identifying clinically relevant cellular responses, as well for pinpointing beneficial interventions. We employed the Affymetrix platform to analyze the whole-...
ORGANISM(S): Rattus norvegicus 
2014-04-22 | E-GEOD-55260 | biostudies-arrayexpress
Transcriptomicsmyocardial infarction in Reg3beta knock-out mice
Affymetrix microarray analysis of molecular changes after myocardial infarction. Samples of heart tissue were analyzed after myocardial infarction from WT and reg3beta knock-out mice. Samples from scar tissue and samples adjacent to the scar were analyzed. In the experiment we primarily compared inf...
ORGANISM(S): Mus musculus 
2015-06-29 | E-MTAB-2561 | biostudies-arrayexpress
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