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ProteomicsCondensin chromatin association is regulated by the combined actions of SMC head and hinge engagement and phosphorylation
The SMC condensin complex is essential for normal mitotic chromosome structure in eukaryotes. Here we undertake a comprehensive analysis of the importance of the condensin ATP binding and hydrolysis, SMC hinge stability and condensin subunit phosphorylation for chromatin association in budding yeast...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-10-14 | PXD006028 | Pride
Cerevisiae yeast condensin phosphorylation 
ProteomicsMolecular mechanism targeting condensin for chromosome condensation.
Faithful chromosome segregation requires packaging of the genome on both global and local scales. Condensin plays a crucial role at pericentromeres to resist spindle forces and ensure the oriented attachment of kinetochores to microtubules at mitosis. Here we demonstrate that budding yeast condensin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-12-10 | PXD056649 | Pride
Condensin Chromosome segregation Slim Cross-linking mass spectrometry Shugoshin 
ProteomicsMolecular mechanism targeting condensin for chromosome condensation
Faithful chromosome segregation requires packaging of the genome on both global and local scales. Condensin plays a crucial role at pericentromeres to resist spindle forces and ensure the oriented attachment of kinetochores to microtubules at mitosis. Here we demonstrate that budding yeast condensin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-12-10 | PXD056626 | Pride
Chromosome segregation Dia Shugoshin Ipms Pericentromeres Condensin 
UnknownCell-Cycle Regulation of Dynamic Chromosome Association of the Condensin Complex.
Not available
S-EPMC5986713 | biostudies-literature
ProteomicsQuantitative Phosphoproteomics reveals new roles for PP6 in chromosome condensation and segregation
Protein phosphorylation by protein kinases and phosphatases is an important regulatory mechanism that controls mitotic progression. Protein Phosphatase 6 (PP6) is an essential enzyme with conserved roles in chromosome segregation and spindle assembly from yeast to humans. Here, we develop a baculovi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-27 | MSV000079201 | MassIVE
TranscriptomicsCohesin localisation along fission yeast chromosomes delineates conserved mechanisms of binding
Cohesin holds sister chromatids together to enable their accurate segregation in mitosis. How, and where, cohesin binds to chromosomes are still poorly understood, and recent genome-wide surveys have revealed an apparent disparity between its chromosomal association patterns in different organisms. ...
ORGANISM(S): Schizosaccharomyces pombe 
2010-05-14 | E-GEOD-13517 | biostudies-arrayexpress
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