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MetabolomicsEicosanoid-immunometabotypes reveal genotypic links to cervicovaginal pH in progestagen synchronized South African Dohne Merino ewes
Eicosanoid-immunometabotypes reveal genotypic links to cervicovaginal pH in progestagen synchronized South African Dohne Merino ewes.
2026-07-16 | MTBLS14823 | MetaboLights
ProteomicsProteomic analysis of cervicovaginal fluid for endometriosis biomarker discovery
Endometriosis is a gynaecological disease facing significant diagnostic challenges, contributing to an extensive diagnostic delay. Non-invasive diagnostic biomarkers of endometriosis could expedite diagnosis and minimise the reliance on surgery to confirm endometriosis. This pilot study aimed to ide...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD065951 | Pride
Cervicovaginal fluid Endometriosis Swath-ms 
ProteomicsQuantitative Proteomic Profiling of Cervicovaginal Fluid from Pregnant Women with Term and Preterm Birth
Preterm birth (PTB) is one of major causes of perinatal mortality and neonatal morbidity, but knowledge of its complex etiology is still limited. Here we present cervicovaginal fluid (CVF) protein profiles of pregnant women who subsequently delivered at spontaneous preterm or term, aiming to identif...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021401 | Pride
Cervicovaginal fluid Preterm birth Quantitative proteomics 
ProteomicsCervicovaginal dysbiosis is associated with significant changes in the cervicovaginal proteome related to immune activation and increased cell death
Cervicovaginal microbiome dysbiosis is associated with increased prevalence and incidence of sexually transmitted infections including HIV. We compared the cervicovaginal proteome as characterised by mass-spectrometry of four groups of African female sex workers (total N=50) grouped by microbiome co...
ORGANISM(S): Homo sapiens (Human) 
2015-09-25 | PXD001435 | Pride
Bacterial vaginosis/ cervicovaginal microbiome/ cervicovaginal proteome/ hiv/ lactobacillus crispatus/ mass spectrometry 
ProteomicsUnique insights in cervicovaginal Lactobacillus iners and L. crispatus proteome changes associated with microbiome dysbiosis
Cervicovaginal lavage (CVL)supernatants were heat inactivated for 30 minutes at 56°C before further processing. Total protein concentrations were determined using the Pierce Coomassie Plus (Bradford) Protein Assay (Thermo Scientific, Rockford, IL, USA). Sample protein content and volume were normali...
ORGANISM(S): Homo sapiens (Human) Lactobacillus iners Lactobacillus crispatus 
2016-03-15 | PXD003176 | Pride
Label free proteomics Cervicovaginal microbiome dysbiosis 
ProteomicsComprehensive spectral library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid
This study focuses on the potential of detecting endometrial cancer based on the proteins and peptides expressed in cervico-vaginal fluid.Sequential window acquisition of all theoretical mass spectra (SWATH-MS), an accurate and reproducible platform for analysing biological samples, offers a technol...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD025925 | Pride
Endemetrial cancer Proteomics Spectral library Biomarkers Cervico-vaginal fluid 
MetabolomicsLACTIN-V (Lactobacillus crispatus CTV-05) leads to microbial and immune modulation in pregnant women at risk of spontaneous preterm birth: FLIP-1 study

Preterm birth (PTB) remains a leading cause of neonatal morbidity and mortality, with no new preventive therapeutics introduced since the 1970s. Evidence increasingly implicates adverse vaginal microbiome-immune interactions in its aetiology. We report the effects of the live biotherapeutic, Lact...

2026-10-02 | MTBLS15899 | MetaboLights
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
UnknownQuantitative cervicovaginal fluid fetal fibronectin: A liquid biopsy for intra-amniotic inflammation.
Not available
S-EPMC11502457 | biostudies-literature
UnknownAnti-HIV-1 Activity of Lactic Acid in Human Cervicovaginal Fluid.
Not available
S-EPMC6034077 | biostudies-literature
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