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TranscriptomicsCFIm25 links alternative polyadenylation to glioblastoma tumour suppression
Purpose: To identify all of the APA targets of CFIm25 on a global scale and develop an algorithm that can idenitify APA events from standard RNA-seq data Methods: RNA from HeLa cells treated with control siRNA and CFIm25 siRNA were subject to RNA-Seq. Using a custom-designed algorithm to mine RNA-s...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-42420 | biostudies-arrayexpress
ProteomicsPartial loss of CFIm25 causes aberrant alternative polyadenylation and learning deficits
We previously showed that NUDT21-spanning copy-number variations (CNVs) are associated with intellectual disability (ID), and that NUDT21-encoded CFIm25 regulates the protein levels of at least one dose-sensitive, ID-associated protein: MeCP2 (Gennarino et al., 2015). However, the patients’ CNVs als...
ORGANISM(S): Homo sapiens (Human) 
2019-08-14 | PXD014842 | Pride
Neurons Intellectual disability (id) Cfim25 Nudt21 Mecp2 
GenomicsComparison of genomic binding profile for CFIm25 in control and CFIm25 KD hESCs (H9 cell line)
Comparison of genomic binding profile for CFIm25 in control and CFIm25 KD hESCs (H9 cell line)
PRJNA737294 | ENA
Genomicspoly(A+)-seq profiling of gene expression in control H9 and (CFIm25 KD+ 3Flag-CFIm25 overexpression) H9 cell lines
poly(A+)-seq profiling of gene expression in control H9 and (CFIm25 KD+ 3Flag-CFIm25 overexpression) H9 cell lines
PRJNA735770 | ENA
GenomicsEffect of CFIm25 knock-out on RNA polymerase II transcription
Effect of CFIm25 knock-out on RNA polymerase II transcription
PRJNA490093 | ENA
Genomics3'-seq analysis in control and CFIm25 depleted HeLa cells
3'-seq analysis in control and CFIm25 depleted HeLa cells
PRJNA1162007 | ENA
GenomicsComparison of genomic binding profile for CFIm25 in control and CFIm25 KD hESCs (H9 cell line)
To understand how CFIm25 associates with genomic DNA during co-transcriptional mRNA processing,we carried out ChIP-seq analysis for CFIm25 in control and CFIm25 KD cells (CFIm25 KD cells as normalization background)
ORGANISM(S): Homo sapiens 
2022-04-21 | GSE178076 | GEO
UnknownCFIm25 links alternative polyadenylation to glioblastoma tumour suppression.
Not available
S-EPMC4128630 | biostudies-literature
Transcriptomicspoly(A+)-seq profiling of gene expression in control H9 and (CFIm25 KD+ 3Flag-CFIm25 overexpression) H9 cell lines
We carried out CFIm25 KD experiments in H9 cell line (hESCs). After poly(A+)-seq, we found the expression of hundreds of genes were changed. To investigate if the effect is a direct or indirect effect of CFIm25 KD, we next carried out 3Flag-CFIm25 overexpression in CFIm25 KD cells for gene-rescue ex...
ORGANISM(S): Homo sapiens 
2022-04-21 | GSE176328 | GEO
GenomicsDownregulation of CFIm25 amplifies dermal fibrosis through Alternative Polyadenylation
Downregulation of CFIm25 amplifies dermal fibrosis through Alternative Polyadenylation
PRJNA564994 | ENA
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