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TranscriptomicsTranscriptional regulation in pluripotent stem cells by Methyl CpG binding protein 2 (MeCP2)
Rett syndrome (RTT) is one of the most prevalent female mental disorders. De novo mutations in methyl CpG binding protein 2 (MeCP2) are a major cause of RTT. MeCP2 regulates gene expression as a transcription regulator as well as through long-range chromatin interaction. Because MeCP2 is present on ...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51607 | biostudies-arrayexpress
TranscriptomicsHypothalamic gene expression data from Mecp2-null and MECP2-transgenic mice
We compared gene expression changes in the hypothalamus of mice lacking MeCP2 (Mecp2-null) and mice overexpressing MeCP2 (MECP2-transgenic). Mutations in the gene encoding the transcriptional repressor methyl-CpG binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome. Loss of ...
ORGANISM(S): Mus musculus 
2008-05-30 | E-GEOD-11150 | biostudies-arrayexpress
GenomicsNeuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state
We report the application of single molecule-based sequencing technology for high-throughput genom-wide mapping of MeCP2 binding and DNA methylation in mouse brain and cerebellum respectively. We find a good correlation between MeCP2 occupancy and methyl-CpG density and depletion of MeCP2 binding at...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-19786 | biostudies-arrayexpress
TranscriptomicsCerebellar gene expression data from Mecp2-null and MECP2-transgenic mice
We compared gene expression changes in the cerebellum of mice lacking MeCP2 (Mecp2-null) and mice overexpressing MeCP2 (MECP2-transgenic). A group of postnatal neurodevelopmental disorders collectively referred to as MeCP2 disorders are caused by aberrations in the gene encoding methyl-CpG-binding ...
ORGANISM(S): Mus musculus 
2010-04-10 | E-GEOD-15574 | biostudies-arrayexpress
TranscriptomicsLoss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome
The goal of this study was to characterize a novel Mecp2 allele in the laboratory rat, a distinct rodent species from the laboratory mouse with unique features. The allele was created by zinc finger-nuclease (ZFN) targeting (SAGE/Horizon) of the X-linked gene, Methyl-CpG-Binding Protein 2 (Mecp2), r...
ORGANISM(S): Rattus norvegicus 
2016-08-09 | E-GEOD-83323 | biostudies-arrayexpress
ProteomicsMeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation
ethyl-CpG-binding protein 2 (MeCP2) is an epigenetic reader essential for neuronal function, but how it binds DNA methylation within chromatin is still unclear. Using designer nucleosomes we observe that MeCP2 preferentially binds DNA methylation positioned at multiple sites around the nucleosome. S...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD064826 | Pride
Mecp2 Cross-linking mass spectrometry Dna methylation Nucleosomes Chromatin 
ProteomicsMeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes
A unique signature of neuronal transcriptomes is the high expression of the longest genes in the genome (e.g. >100 kilobases). These genes encode proteins with essential functions in neuronal physiology, and disruption of long gene expression has been implicated in neurological disorders. DNA topois...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-15 | PXD046904 | Pride
Neuron Mecp2 Immunoprecipitation 
TranscriptomicsIntragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition [RNA-Seq]
Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body regions remains incompletely understood. Here, we show that DNA methylation is enr...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-47488 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human differentiated vs. undifferentiated SH-SY5Y cells transfected with a MeCP2 (transcriptional repressor) decoy to investigate the neurodevelopmental disorder Rett syndrome
Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder caused by mutations in MECP2, encoding methyl-CpG-binding protein 2. MeCP2 is a transcriptional repressor elevated in mature neurons and is predicted to be required for neuronal maturation by regulating multiple target genes. Id...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4600 | biostudies-arrayexpress
TranscriptomicsExpression data of Myh6-MeCP2 transgenic mice
Hearts of Myh6-MeCP2 transgenic mice and wildtype littermates were rapidly dissected and flash frozen. We used Affymetrix microarrays to assess gene expression changes induced by overexpression of MeCP2 under the control of a cardiomycyte specific promoter. Hearts were dissected 2-3 weeks after birt...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-52797 | biostudies-arrayexpress
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