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GenomicsScreening for abnormal CGI methylation in primary colorectal tumours
A common hallmark of neoplastic cells is abnormal acquisition of CpG island (CGI) methylation and the silencing of associated gene promoters. To determine the extent and distribution of CGI methylation in colorectal cancer, we solexa sequenced MBD affinity purified DNA prepared from five colorectal ...
EGAS00001000076 | EGA
GenomicsComprehensive analysis of orphan CpG islands identifes novel promoters with conserved DNA methylation dynamics
We report the application of single molecule-based sequencing technology in combination with CXXC affinity purifcation (CAP-seq), MBD affinity purification (MAP-seq) and chromatin immunoprecipitation (ChIP-seq) to generate reciprocal methylation and chromatin modifcation maps in human and mouse. We ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-21442 | biostudies-arrayexpress
ProteomicsBANP is an essential transcription factor that opens chromatin and activates CpG island regulated genes
While the majority of RNA polymerase II initiation events in mammalian genomes take place within CpG island (CGI) promoters, our understanding of their regulation remains limited. Here we combine single-molecule footprinting with interaction proteomics to identify BANP as a critical CGI regulator an...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-16 | PXD024794 | Pride
Cpg island Single-molecule footprinting Cgi promoters Banp Tf binding Paqman 
GenomicsMBD-Seq of human primary colorectal tumours to explore abnormal CGI methylation
A common hallmark of neoplastic cells is abnormal acquisition of CpG island (CGI) methylation and the silencing of associated gene promoters. To determine the extent and distribution of CGI methylation in colorectal cancer, we solexa sequenced MBD affinity purified DNA prepared from five colorectal ...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-ERAD-12 | biostudies-arrayexpress
GenomicsCell Type-Specific DNA Methylation at Intragenic CpG Islands in the Immune System (MAP-Seq and ChIP-Seq data)
Human and mouse genomes contain a similar number of CpG islands (CGIs), which are discrete CpG-rich DNA sequences associated with transcription start sites. In both species, about 50% of all CGIs are remote from annotated promoters, but nevertheless often have promoter-like features. To document the...
ORGANISM(S): Mus musculus 
2011-05-23 | E-GEOD-25688 | biostudies-arrayexpress
UnknownDistal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters.
Not available
S-EPMC5378174 | biostudies-literature
UnknownDifferential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancer.
Not available
S-EPMC6398885 | biostudies-literature
Genomics5-hydroxymethylcytosine: the sixth DNA base
We performed a meta analysis of publicly available TET1, 5mC, 5hmC and genome wide bisulfite profiling data mostly from mouse embryonic stem cells (ESC). Genome wide chromatin immunoprecipitation combined with deep sequencing (ChIP-seq) has revealed binding of the TET1 protein at CpG-island (CGI) pr...
ORGANISM(S): Mus musculus 
2011-11-24 | E-GEOD-31343 | biostudies-arrayexpress
GenomicsKDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity [ATAC-seq]
CpG islands (CGI) are associated with the majority of mammalian gene promoters and function to recruit chromatin modifying enzymes. It has therefore been proposed that CGIs regulate gene expression through chromatin-based mechanisms, however in most cases this has not been directly tested. Here, we ...
ORGANISM(S): Mus musculus 
2019-07-03 | GSE126863 | GEO
GenomicsKDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity [ChIP-seq]
CpG islands (CGI) are associated with the majority of mammalian gene promoters and function to recruit chromatin modifying enzymes. It has therefore been proposed that CGIs regulate gene expression through chromatin-based mechanisms, however in most cases this has not been directly tested. Here, we ...
ORGANISM(S): Mus musculus 
2019-07-03 | GSE126862 | GEO
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